Comparative Efficacy of ALK Inhibitors for Treatment-Naïve ALK-Positive Advanced Non-Small Cell Lung Cancer with Central Nervous System Metastasis: A Network Meta-Analysis

Andō, Koichi; Manabe, Ryo; Kishino, Yasunari; Kusumoto, Sojiro; Yamaoka, Toshimitsu; Tanaka, Akihiko; Ohmori, Tohru; Sagara, Hironori

doi:10.3390/ijms24032242

Public

Comparative Efficacy of ALK Inhibitors for Treatment-Naïve ALK-Positive Advanced Non-Small Cell Lung Cancer with Central Nervous System Metastasis: A Network Meta-Analysis

Published in International Journal of Molecular Sciences • Jan 23, 2023

Authors:

Koichi Andō

Ryo Manabe

Yasunari Kishino

Abstract

Central nervous system (CNS) metastases and acquired resistance complicate the treatment of anaplastic lymphoma kinase (ALK) rearrangement-positive (ALK-p) advanced non-small cell lung cancer (NSCLC). Thus, this review aimed to provide a comprehensive overview of brain metastasis, acquired resistanc...

Subject

Ceritinib

Alectinib

Anaplastic lymphoma kinase

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