Sustained Response with Dose Reduced Selpercatinib in a Pediatric Patient with Metastatic NCOA4-RET Fusion Papillary Thyroid Carcinoma

C. Suydam, Anna; Bach, Alicia; Markovina, Stephanie; W. Grigsby, Perry; Sprague, Jennifer; E. Armstrong, Amy

doi:10.22541/au.167446630.05113063/v1

Public

Sustained Response with Dose Reduced Selpercatinib in a Pediatric Patient with Metastatic NCOA4-RET Fusion Papillary Thyroid Carcinoma

Published • Jan 23, 2023

Authors:

Anna C. Suydam

Alicia Bach

Stephanie Markovina

Abstract

Understanding the molecular landscape of papillary thyroid carcinoma (PTC), the most common thyroid cancer in children, creates additional therapeutic approaches. RET gene rearrangements are observed in pediatric PTC and selective inhibition of RET is now possible with specific tyrosine kinase inhib...

Subject

Thyroid carcinoma

Medicine

Papillary thyroid cancer

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