Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

Demontis, Ditte; Bragi Walters, G.; Athanasiadis, Georgios; K. Walters, Raymond; Therrien, Karen; Tollerup Nielsen, Trine; Farajzadeh, Leila; Voloudakis, Georgios; Bendl, Jaroslav; Zeng, Biau; Zhang, Wen; Grove, Jakob; D. Als, Thomas; Duan, Jinjie; Kyle Satterstrom, F.; Bybjerg‐Grauholm, Jonas; Bækved-Hansen, Marie; Ó. Guðmundsson, Ólafur; H. Magnússon, Sigurður; Baldursson, Gísli; Davíðsdóttir, Katrín; S. Haraldsdóttir, Gyða; Agerbo, Esben; E. Hoffman, Gabriel; Dalsgaard, Søren; Martin, Joanna; Ribasés, Marta; I. Boomsma, Dorret; Soler Artigas, María; Roth Mota, Nina; P. Howrigan, Daniel; E. Medland, Sarah; Zayats, Tetyana; M. Rajagopal, Veera; Havdahl, Alexandra; E. Doyle, Alysa; Reif, Andreas; Thapar, Anita; Cormand, Bru; Liao, Calwing; L. Burton, Christie; H.D. Bau, Claiton; Luiz Rovaris, Diego; Sonuga‐Barke, Edmund; C. Corfield, Elizabeth; H. Grevet, Eugênio; Larsson, Henrik; R. Gizer, Ian; D. Waldman, Irwin; Brikell, Isabell; Haavik, Jan; Crosbie, Jennifer; J. McGough, James; Kuntsi, Jonna; Glessner, Joseph; Langley, K.; Lesch, Klaus‐Peter; Augusto Rohde, Luís; Helena Hutz, Mara; Klein, Marieke; A. Bellgrove, Mark; Tesli, Martin; O‘Donovan, Michael; A. Andreassen, Ole; W. L. Leung, Patrick; Mário Pan, Pedro; Joober, Ridha; Schachar, Russell; K. Loo, Sandra; H. Witt, Stephanie; Reichborn‐Kjennerud, Ted; Banaschewski, Tobias; Hawi, Ziarih; J. Daly, Mark; Mors, Ole; Nordentoft, Merete; Mors, Ole; M. Hougaard, David; Bo Mortensen, Preben; J. Daly, Mark; V. Faraone, Stephen; Stefánsson, Hreinn; Roussos, Panos; Franke, Barbara; Werge, Thomas; M. Neale, Benjamin; Stefánsson, Kāri; D. Børglum, Anders

doi:10.1038/s41588-022-01285-8

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Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

Published in Nature Genetics • Jan 26, 2023

Authors:

Ditte Demontis

G. Bragi Walters

Georgios Athanasiadis

Abstract

Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loc...

Subject

Biology

Genetic architecture

Genome-wide association study

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