Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer

J. Hanley, Christopher; Waise, Sara; J. Ellis, Matthew; A. Lopez, Maria; Y. Pun, Wai; Taylor, Julian; Parker, Rachel; Kimbley, Lucy; Chee, Serena; Shaw, Emily; West, Jonathan; Alzetani, Aiman; Woo, Edwin; H. Ottensmeier, Christian; Rose‐Zerilli, Matthew; J. Thomas, Gareth

doi:10.1038/s41467-023-35832-6

Public

Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer

Published in Nature Communications • Jan 31, 2023

Authors:

Christopher J. Hanley

Sara Waise

Matthew J. Ellis

Abstract

Fibroblasts are poorly characterised cells that variably impact tumour progression. Here, we use single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry (CIBERSORTx) to identify and characterise three major fibroblast subpopulations in human non-small cell lung cancer: adv...

Subject

Fibroblast

Myofibroblast

Lung cancer

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