NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8

Anandhan, Annadurai; Dodson, Matthew; Shakya, Aryatara; Chen, Jinjing; Liu, Pengfei; Wei, Yongyi; Tan, Hui; Wang, Qian; Jiang, Ziyan; Yang, Kevin; GN Garcia, Joe; K. Chambers, Setsuko; Chapman, Eli; Ooi, Aikseng; Yang-Hartwich, Yang; R. Stockwell, Brent; D. Zhang, Donna

doi:10.1126/sciadv.ade9585

Public

NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8

Shared by NobleBlocks on Feb 3, 2023 • 12:00 AM UTC

Authors:

Annadurai Anandhan

Matthew Dodson

Aryatara Shakya

Abstract

Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron homeostasis by controlling HERC2 (E3 ubiquitin ligase for NCOA4 and FBXL5) and VAMP8 (mediates autophagosome-lysosome ...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!