Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction

High levels of lactate are positively associated with the prognosis and mortality in patients with heart attack. Endothelial-to-mesenchymal transition (EndoMT) plays an important role in cardiac fibrosis. Here, we report that lactate exerts a previously unknown function that increases cardiac fibros... View More