Genome-wide screening reveals the genetic basis of mammalian embryonic eye development

M. Chee, Justine; Lanoue, Louise; Clary, Dave; Higgins, Kendall; Bower, Lynette; M. Flenniken, Ann; Guo, Ruolin; J. Adams, David; Bosch, Fátima; E. Braun, Robert; D. M. Brown, Steve; Chin, Hyungjin; E. Dickinson, Mary; Hsu, Chih‐Wei; S. Dobbie, Michael; Gao, Xiang; Galande, Sanjeev; Grobler, Anne; D. Heaney, Jason; Hérault, Yann; Hrabě de Angelis, Martin; Mammano, Fabio; M. J. Nutter, Lauryl; Parkinson, Helen; Qin, Chuan; Shiroishi, Toshi; Sedláček, Radislav; Kyung Seong, Je; Xu, Ying; L. Ackert‐Bicknell, Cheryl; E. Adams, Douglas; Adoum, Anne‐Tounsia; Antonio Aguilar‐Pimentel, Juan; Akoma, Uchechukwu; Ali-Hadji, Dalila; V. Amarie, Oana; André, Philippe; Auburtin, Aurélie; Bam’Hamed, Chaouki; Beckers, Johannes; Beig, Joachim; Berberovic, Zorana; Bezginov, Alexandr; Birling, Marie‐Christine; Boroviak, Katharina; Bottomley, Joanna; Bürger, Antje; H. Busch, Dirk; C. Butterfield, Natalie; Cacheiro, Pilar; Calzada‐Wack, Julia; L. Cambridge, Emma; Camilleri, Susan; Champy, Marie‐France; Cater, Heather; Charles, Philippe; J. Chesler, Elissa; Cho, Yi-Li; E. Christiansen, Audrey; Cipriani, Valentina; Cockle, Nicola; Codner, Gemma; Creighton, Amie; Cruz, Maribelle; F. Curry, Katharine; D’Souza, Abigail; Danisment, Ozge; Delbarre, Daniel; F. Dewhurst, Hannah; Doe, Brendan; Dorr, Alex; Giesert, Florian; Duddy, Graham; Duffin, Kyle; El Amri, Amal; Elrick, Hillary; Eskandarian, Mohammad; Fray, Martin; Frost, Anthony; Fuchs, Helmut; Gailus‐Durner, Valérie; Kristine Gampe, Karen; Ganguly, Milan; Gannon, David; Garrett, Lillian; Gertsenstein, Marina; Gleeson, Diane; O. Goodwin, Leslie; Graw, Jochen; Grimsrud, Kristin; Haselimashhadi, Hamed; Hobson, Liane; Hörlein, Andreas; M. Hölter, Sabine; Hong, Seung-Hyun; Horner, Neil; Trainor, Amanda; Huang, Ziyue; Kane, Coleen; Katsman, Yulia; C. Keith, Lance; Kelsey, Lois; Kenyon, Janet; King, Ruairidh; Keskivali-Bond, Piia; Kirton, Andrea; Klein‐Rodewald, Tanja; Klopstock, Thomas; Komla‐Ebri, Davide; Konopka, Tomasz; Kühn, Ralf; Kussy, Fiona; Lafont, David; Lan, Qing; G. Lanza, Denise; Laurin, Valerie; Le Marchand, Elise; Leblanc, Sophie; D. Leitch, Victoria; Lelliott, Chris; Lengger, Christoph; G. Lintott, Lauri; G. Logan, John; Lorenzo, Isabel; Mallon, Ann‐Marie; S. Mannan, Naila; Marschall, Susan; L. McElwee, Melissa; Mckay, Matthew; S. B. McLaren-Jones, Robbie; Mason, Jeremy; F. Meehan, Terrence; Craig Miller, D.; Moore, Michayla; Muñoz‐Fuentes, Violeta; A. Murray, Stephen; Nguyen-Bresinsky, Dong; Oritz, Oskar; Pandis, Panos; Parlog, Alexandru; Patel, Amit; Pavlovic, Guillaume; Pereira, Monica; A. Peterson, Kevin; M. Philip, Vivek; S. Pollard, Andrea; Procházka, Jan; Qu, Dawei; Ramirez, Ayexa; Rangarajan, Sean; L. Rasmussen, Tara; Rathkolb, Birgit; Relac, Mike; Roberton, Kyle; Roper, Willson; Rousseau, Stéphane; W. Rowe, David; Rozman, Jan; Ryan, Jennifer; J. Ryder, Edward; Santos, Luís; Sanz‐Moreno, Adrián; Schick, Joel; Seavey, Zachary; R. Seavitt, John; Seisenberger, Claudia; Selloum, Mohammed; Shang, Xueyuan; Shin, Dong‐Guk; Simon, Michelle; Sleep, Gillian; Smedley, Damian; Sorg, Tania; C. Sparkes, Penny; Spielmann, Nadine; Steinkamp, Ralph; Stewart, Michelle; Stoeger, Claudia; Straiton, Ewan; L. Svenson, Karen; Swash, Holly; Teboul, Lydia; Tondat, Sandra; Treise, Irina; Tudor, Catherine; Urban, Rachel; E. Vancollie, Valerie; Vasseur, Laurent; Vukobradovic, Igor; Wardle‐Jones, Hannah; Warren, Jonathan; Wattenhofer‐Donzé, Marie; E. Wells, Sara; K. White, Jacqueline; Wiegand, Jean-Paul; Willett, Amelia; Witmeyer, Catherine; Wolf, Eckhard; Wong, Leeyean; Wood, Joshua; Wurst, Wolfgang; K. Xu, Catherine; Zimprich, Annemarie; P. Brooks, Brian; McKerlie, Colin; C. Kent Lloyd, K.; Westerberg, Henrik; Moshiri, Ala

doi:10.1186/s12915-022-01475-0

Public

Genome-wide screening reveals the genetic basis of mammalian embryonic eye development

Published in BMC Biology • Feb 3, 2023

Authors:

Justine M. Chee

Louise Lanoue

Dave Clary

Abstract

BACKGROUND: Microphthalmia, anophthalmia, and coloboma (MAC) spectrum disease encompasses a group of eye malformations which play a role in childhood visual impairment. Although the predominant cause of eye malformations is known to be heritable in nature, with 80% of cases displaying loss-of-functi...

Subject

Eye development

Microphthalmia

Biology

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