Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment.

Deplanque, Dominique; Gelé, Patrick; Pétrault, Olivier; Six, Isabelle; Furman, Christophe; Bouly, Muriel; Nion, Stéphane; Dupuis, B; Leys, Didier; Fruchart, Jean‐Charles; Cecchelli, Roméo; Staels, Bart; Duriez, Patrick; Bordet, Régis

doi:10.1523/jneurosci.23-15-06264.2003

Public

Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment.

Published in PubMed • Jul 16, 2003

Authors:

Dominique Deplanque

Patrick Gelé

Olivier Pétrault

Abstract

The treatment of ischemic strokes is limited to the prevention of cerebrovascular risk factors and to the modulation of the coagulation cascade during the acute phase. A new therapeutic strategy could be to preventively protect the brain against noxious biological reactions induced by cerebral ische...

Subject

Neuroprotection

Fenofibrate

Peroxisome proliferator-activated receptor

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