Innate sensing of picornavirus infection involves cGAS-STING-mediated antiviral responses triggered by mitochondrial DNA release

Liu, Huisheng; Zhu, Zixiang; Qiao, Xue; Yang, Fan; Li, Zongqiang; Xue, Zhaoning; Cao, Weijun; He, Jijun; Guo, Jianhong; Liu, Xiangtao; E. Shaw, Andrew; P. King, Donald; Zheng, Haixue

doi:10.1371/journal.ppat.1011132

Public

Innate sensing of picornavirus infection involves cGAS-STING-mediated antiviral responses triggered by mitochondrial DNA release

Published in PLoS Pathogens • Feb 6, 2023

Authors:

Huisheng Liu

Zixiang Zhu

Xue Qiao

Abstract

Cyclic GMP-AMP synthase (cGAS) plays a key role in the innate immune responses to both DNA and RNA virus infection. Here, we found that enterovirus 71 (EV-A71), Seneca Valley virus (SVV), and foot-and-mouth disease virus (FMDV) infection triggered mitochondria damage and mitochondrial DNA (mtDNA) re...

Subject

Picornavirus

Innate immune system

Mitochondrial DNA

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