Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo

Kulaj, Konxhe; Harger, Alexandra; Bauer, M.; Şehnaz Çalışkan, Özüm; Kumar Gupta, Tilak; Menglin Chiang, Dapi; Milbank, Edward; Reber, Josefine; Karlas, Angelos; Kotzbeck, Petra; N. Sailer, David; Volta, Francesco; Lutter, Dominik; Prakash, Sneha; Merl‐Pham, Juliane; Ntziachristos, Vasilis; Hauner, Hans; W. Pfaffl, Michael; H. Tschöp, Matthias; D. Müller, Timo; M. Hauck, Stefanie; D. Engel, Benjamin; M. Gerdes, Jantje; T. Pfluger, Paul; Krahmer, Natalie; Stemmer, Kerstin

doi:10.1038/s41467-023-36148-1

Public

Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo

Published in Nature Communications • Feb 9, 2023

Authors:

Konxhe Kulaj

Alexandra Harger

M. Bauer

Abstract

Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that convey communication from adipose tissue to other organs. Here, to delineate their role as messengers with glucoregulatory nature, we paired fluorescence AdEV-tracing and SILAC-labeling with (phospho)proteomics, and r...

Subject

Secretion

Extracellular vesicles

Vesicle

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