Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Tintelnot, Joseph; Xu, Yang; Robin Lesker, Till; Schönlein, Martin; Konczalla, Leonie; D. Giannou, Anastasios; Pelczar, Penelope; Kylies, Dominik; G. Puelles, Victor; A. Bielecka, Agata; Peschka, Manuela; Cortesi, Filippo; Riecken, Kristoffer; Jung, Maximilian; Amend, Lena; Sebastian Bröring, Tobias; Trajkovic‐Arsic, Marija; T. Siveke, Jens; Renné, Thomas; Zhang, Danmei; Boeck, Stefan; Strowig, Till; G. Uzunoǧlu, Faik; Güngör, Cenap; Stein, Alexander; R. Izbicki, Jakob; Bokemeyer, Carsten; Sinn, Marianne; C. Kimmelman, Alec; Huber, Samuel; Gagliani, Nicola

doi:10.1038/s41586-023-05728-y

Public

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Published in Nature • Feb 22, 2023

Authors:

Joseph Tintelnot

Yang Xu

Till Robin Lesker

Abstract

Abstract Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment 1,2 . Less than half of all patients respond to the primary treatment for PDAC, chemotherapy 3,4 , and geneti...

Subject

Cancer research

Pancreatic cancer

Cancer

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