Co-Transplantation of Barcoded Lymphoid-Primed Multipotent (LMPP) and Common Lymphocyte (CLP) Progenitors Reveals a Major Contribution of LMPP to the Lymphoid Lineage

Michaels, Victoria; Chalabi, Smahane; Legrand, Agnès; Renard, Julie; Tejerina, Emmanuel; Daouya, Marina; Fabrega, Sylvie; Megret, Jérôme; Olaso, Robert; Boland, Anne; Deleuze, Jean‐François; Battail, Christophe; Tronik‐Le Roux, Diana; Ezine, Sophie

doi:10.3390/ijms24054368

Public

Co-Transplantation of Barcoded Lymphoid-Primed Multipotent (LMPP) and Common Lymphocyte (CLP) Progenitors Reveals a Major Contribution of LMPP to the Lymphoid Lineage

Published in International Journal of Molecular Sciences • Feb 22, 2023

Authors:

Victoria Michaels

Smahane Chalabi

Agnès Legrand

Abstract

T cells have the potential to maintain immunological memory and self-tolerance by recognizing antigens from pathogens or tumors. In pathological situations, failure to generate de novo T cells causes immunodeficiency resulting in acute infections and complications. Hematopoietic stem cells (HSC) tra...

Subject

Biology

Progenitor cell

Transplantation

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