Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma

Lapitz, Ainhoa; Azkargorta, Mikel; Milkiewicz, Piotr; Olaizola, Paula; Zhuravleva, Ekaterina; M. Grimsrud, Marit; Schramm, Christoph; Arbelaiz, Ander; J. O’Rourke, Colm; La Casta, Adelaida; Milkiewicz, Małgorzata; Pastor, Tania; Vesterhus, Mette; Jiménez-Agüero, Raúl; T. Dill, Michael; Lamarca, Ángela; W. Valle, Juan; I.R. Macı́as, Rocı́o; Izquierdo‐Sánchez, Laura; Pérez Castaño, Ylenia; J. Caballero‐Camino, Francisco; Riaño, Ioana; Krawczyk, Marcin; Ibarra, Cesar; Bustamante, Javier; M. Nova‐Camacho, Luiz; Manuel Falcón‐Pérez, Juan; Elortza, Félix; J. Perugorria, María; B. Andersen, Jesper; Bujanda, Luís; H. Karlsen, Tom; Folseraas, Trine; M. Rodrigues, Pedro; M. Bañales, Jesús

doi:10.1016/j.jhep.2023.02.027

Public

Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma

Published in Journal of Hepatology • Mar 1, 2023

Authors:

Ainhoa Lapitz

Mikel Azkargorta

Piotr Milkiewicz

Abstract

•Circulating EV-proteins allow for CCA risk prediction, early and differential (vs. HCC) diagnosis, and prognostication.•Serum CRP/FIBRINOGEN/FRIL levels discriminated patients with early-stage PSC-CCA from those with PSC.•Most pan-CCA biomarkers are mainly expressed in malignant cholangiocytes with...

Subject

Medicine

Liquid biopsy

Radiology

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