PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway

Zhang, Rui; Dong, Mengxue; Tu, Juchuanli; Li, Fengkai; Deng, Qiaodan; Xu, Jiahui; He, Xue‐Yan; Ding, Jiajun; Xia, Jie; Sheng, Dandan; Chang, Zhaoxia; Ma, Wei; Dong, Haonan; Zhang, Yi; Zhang, Lixing; Zhang, Lu; Zhang, Lu; Zhang, Lu; Liu, Suling

doi:10.1038/s41392-023-01337-3

Public

PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway

Published in Signal Transduction and Targeted Therapy • Mar 1, 2023

Authors:

Rui Zhang

Mengxue Dong

Juchuanli Tu

Abstract

Abstract Our previous studies have showed that C-C motif chemokine ligand 20 (CCL20) advanced tumor progression and enhanced the chemoresistance of cancer cells by positively regulating breast cancer stem cell (BCSC) self-renewal. However, it is unclear whether CCL20 affects breast cancer progressio...

Subject

CXCL2

Cancer cell

CCL20

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