Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients

E. Nissen, Steven; Michael Lincoff, A.; M. Brennan, Danielle; K. Ray, Kausik; Mason, Denise; J.P. Kastelein, John; D. Thompson, Paul; Libby, Peter; Cho, Leslie; Plutzky, Jorge; Bays, Harold; M. Moriarty, Patrick; Menon, Venu; E. Grobbee, Diederick; J. Louie, Michael; Chen, Chien‐Feng; Li, Na; T. Bloedon, LeAnne; Robinson, Paula; Horner, Maggie; J. Sasiela, William; McCluskey, Jackie; Davey, Deborah; Fajardo-Campos, Pedro; Petrović, Predrag; Fedačko, Ján; Żmuda, Witold; Lukyanov, Yury; J. Nicholls, Stephen

doi:10.1056/nejmoa2215024

Public

Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients

Published in New England Journal of Medicine • Mar 4, 2023

Authors:

Steven E. Nissen

A. Michael Lincoff

Danielle M. Brennan

Abstract

BACKGROUND: Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein (LDL) cholesterol levels and is associated with a low incidence of muscle-related adverse events; its effects on cardiovascular outcomes remain uncertain. METHODS: We conducted a double-blind, randomized, pla...

Subject

Statin

Medicine

Internal medicine

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