Fumarate induces vesicular release of mtDNA to drive innate immunity

Zecchini, Vincent; Paupe, Vincent; Herranz-Montoya, Irene; J. E. Janssen, Joëlle; M. N. Wortel, Inge; L. Morris, Jordan; N. Ferguson, Ashley; Roy Chowdury, Suvagata; Segarra‐Mondejar, Marc; S.H. Costa, Ana; C. Pereira, Gonçalo; Tronci, Laura; J. Young, Timothy; Nikitopoulou, Efterpi; Yang, Ming; Bihary, Dóra; Caicci, Federico; Nagashima, Shun; Speed, Alyson; Bokea, Kalliopi; Baig, Zara; Samarajiwa, Shamith; Tran, Maxine; J. Mitchell, Thomas; Johnson, Mark; Prudent, Julien; Frezza, Christian

doi:10.1038/s41586-023-05770-w

Public

Fumarate induces vesicular release of mtDNA to drive innate immunity

Published in Nature • Mar 8, 2023

Authors:

Vincent Zecchini

Vincent Paupe

Irene Herranz-Montoya

Abstract

Abstract Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma 1 . Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate 2 . However, although the long-term consequences of FH loss have b...

Subject

Fumarase

Cell biology

Biology

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