Revisiting the Mesenchymal “Stem vs. Stromal” Cell Dichotomy and Its Implications for Development of Improved Potency Metrics

G. Phinney, Donald; Hwa Lee, Ryang; V. Boregowda, Siddaraju

doi:10.1093/stmcls/sxad019

Public

Revisiting the Mesenchymal “Stem vs. Stromal” Cell Dichotomy and Its Implications for Development of Improved Potency Metrics

Published in Stem Cells • Mar 8, 2023

Authors:

Donald G. Phinney

Ryang Hwa Lee

Siddaraju V. Boregowda

Abstract

Mesenchymal stem/stromal cell (MSC)-based therapies have been evaluated in over 1500 human clinical trials for a diverse array of disease indication, but outcomes remain unpredictable due to knowledge gaps in the quality attributes that confer therapeutic potency onto cells and their mode of action ...

Subject

Paracrine signalling

Mesenchymal stem cell

Biology

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