Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis

Lin, Qisheng; Li, Shu; Jin, Haijiao; Cai, Hong; Zhu, Xuying; Yang, Yuanting; Wu, Jingkui; Qi, Chaojun; Shao, Xinghua; Li, Jialin; Zhang, Kaiqi; Zhou, Wenyan; Zhang, Minfang; Cheng, Jiayi; Gu, Leyi; Mou, Shan; Ni, Zhaohui

doi:10.7150/ijbs.80775

Public

Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis

Published in International Journal of Biological Sciences • Jan 1, 2023

Authors:

Qisheng Lin

Shu Li

Haijiao Jin

Abstract

knockout cisplatin-treated mice. Ferrstatin-1, a synthetic antioxidative ferroptosis inhibitor, rescued iron accumulation, lipid peroxidation and ferroptosis caused by inhibition of mitophagy. Thus, the present study elucidated a novel mechanism by which both BNIP3-mediated and PINK1-PARK2-mediated ...

Subject

Mitophagy

Lipid peroxidation

PINK1

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