Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation

Zhou, Cong; Yu, Ting; Zhu, Rui; Lu, Junjie; Ouyang, Xiaohu; Zhang, Zili; Chen, Qianyun; Li, Junyi; Cui, Jing; Jiang, Feng; Yun Jin, Kim; Sarapultsev, Alexey; Li, Fangfei; Zhang, Ge; Luo, Shanshan; Hu, Desheng

doi:10.7150/ijbs.77979

Public

Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation

Published in International Journal of Biological Sciences • Jan 1, 2023

Authors:

Cong Zhou

Ting Yu

Rui Zhu

Abstract

ubiquitination assay. In addition, Tim-AIII inhibited cell proliferation, induced cell death, led to ROS and iron accumulation, MDA production, GSH depletion, as well as GPX4 ubiquitination and degradation, were markedly abrogated when HSP90 was knockdown by HSP90-shRNA transfection. Importantly, Ti...

Subject

Programmed cell death

Cell growth

Glutathione

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