Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma

A. Walentynowicz, Kacper; Engelhardt, Dalit; Cristea, Simona; Yadav, Shreya; Onubogu, Ugoma; Salatino, Roberto; Maerken, Melanie; Vincentelli, Cristina; Jhaveri, Aashna; Geisberg, Jacob; O. McDonald, Thomas; Michor, Franziska; Janiszewska, Michalina

doi:10.1016/j.celrep.2023.112235

Public

Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma

Published in Cell Reports • Mar 1, 2023

Authors:

Kacper A. Walentynowicz

Dalit Engelhardt

Simona Cristea

Abstract

Glioblastoma (GBM) is the most aggressive brain tumor, with a median survival of ∼15 months. Targeted approaches have not been successful in this tumor type due to the large extent of intratumor heterogeneity. Mosaic amplification of oncogenes suggests that multiple genetically distinct clones are p...

Subject

Biology

Fluorescence in situ hybridization

PDGFRA

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