Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

Hu, Zongqiang; Chen, Gang; Zhao, Yingpeng; Gao, Hongqiang; Li, Laibang; Li, Laibang; Yin, Yanfeng; Jiang, Jie; Mang, Yuanyi; Mang, Yuanyi; Gao, Yang; Zhang, Shengning; Ran, Jianghua; Li, Li; Li, Li

doi:10.1186/s12943-023-01759-1

Public

Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

Published in Molecular Cancer • Mar 18, 2023

Authors:

Zongqiang Hu

Gang Chen

Yingpeng Zhao

Abstract

BACKGROUND: Circular RNAs (circRNAs) can be encapsulated into exosomes to participate in intercellular communication, affecting the malignant progression of a variety of tumors. Dysfunction of CD8 + T cells is the main factor in immune escape from hepatocellular carcinoma (HCC). Nevertheless, the ef...

Subject

Biology

Cancer research

Exosome

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