Indoxyl-sulfate activation of the AhR- NF-κB pathway promotes interleukin-6 secretion and the subsequent osteogenic differentiation of human valvular interstitial cells from the aortic valve

Candellier, Alexandre; Issa, Nervana; Grissi, Maria; Brouette, Théo; Avondo, Carine; Gomila, Cathy; Blot, Gérémy; Gubler, Brigitte; Touati, Gilles; Bennis, Youssef; Caus, Thierry; Brazier, Michel; Choukroun, Gabriel; Tribouilloy, Christophe; Kamel, Saïd; Boudot, Cédric; Hénaut, Lucie; Eltchaninoff, Hélène; Bellien, Jérémy; Bertrand, Benjamin; Beygui, Farzin; Béziau-Gasnier, Delphine; Bråkenhielm, Ebba; Caligiuri, Giuseppina; Chevreul, Karine; Debroucker, Frédérique; Durand, Éric; Fraschini, Christophe; Gilard, Martine; Iung, Bernard; Kamel, Saïd; Khallou‐Laschet, Jamila; Manrique, Alain; Messas, Emmanuel; Messika–Zeitoun, David; Pinet, F; Richard, Vincent; Saloux, Eric; Thoenes, Martin; Tribouilloy, Christophe; Vézier, Claire

doi:10.1016/j.yjmcc.2023.03.011

Public

Indoxyl-sulfate activation of the AhR- NF-κB pathway promotes interleukin-6 secretion and the subsequent osteogenic differentiation of human valvular interstitial cells from the aortic valve

Published in Journal of Molecular and Cellular Cardiology • Mar 24, 2023

Authors:

Alexandre Candellier

Nervana Issa

Maria Grissi

Abstract

BACKGROUND: Calcific aortic stenosis (CAS) is more prevalent, occurs earlier, progresses faster and has worse outcomes in patients with chronic kidney disease (CKD). The uremic toxin indoxyl sulfate (IS) is powerful predictor of cardiovascular mortality in these patients and a strong promoter of ect...

Subject

Secretion

Cancer research

Cell biology

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