Vedolizumab for the Treatment of Chronic Pouchitis

Travis, Simon; S. Silverberg, Mark; Danese, Silvio; Gionchetti, Paolo; Löwenberg, Mark; Jairath, Vipul; G. Feagan, Brian; Bressler, Brian; Ferrante, Marc; Hart, Ailsa; Lindner, Dirk; Escher, Armella; E. Jones, Stephen; Shen, Bo

doi:10.1056/nejmoa2208450

Public

Vedolizumab for the Treatment of Chronic Pouchitis

Published in New England Journal of Medicine • Mar 29, 2023

Authors:

Simon Travis

Mark S. Silverberg

Silvio Danese

Abstract

BACKGROUND: Approximately half the patients with ulcerative colitis who undergo restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) will subsequently have pouchitis, and among those patients, one fifth will have chronic pouchitis. METHODS: We conducted a phase 4, double-blind, rando...

Subject

Vedolizumab

Pouchitis

Medicine

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