Genomic investigations of unexplained acute hepatitis in children

Morfopoulou, Sofia; Buddle, Sarah; Enrique Torres Montaguth, Oscar; Atkinson, Laura; Afonso Guerra‐Assunção, José; Moradi Marjaneh, Mahdi; Zennezini Chiozzi, Riccardo; Storey, Nathaniel; Campos, Luis; Ciaran Hutchinson, J.; R. Counsell, John; Pollara, Gabriele; Roy, Sunando; Venturini, Cristina; F. Antinao Diaz, Juan; Siam, Ala’a; J. Tappouni, Luke; Asgarian, Zeinab; Ng, Joanne; S. Hanlon, Killian; Lennon, Alexander; McArdle, Andrew; Czap, Agata; Rosenheim, Joshua; Andrade, Catarina; Anderson, Glenn; C. D. Lee, Jack; Williams, Rachel; A. Williams, Charlotte; J. Tutill, Helena; Bayzid, Nadua; Marina Martin Bernal, Luz; Macpherson, Hannah; Montgomery, Kylie-Ann; Moore, Catherine; Templeton, Kate; Neill, Claire; T. G. Holden, Matthew; Gunson, Rory; J. Shepherd, Samantha; Shah, Priyen; Cooray, Samantha; Voice, Marie; Steele, M.A.; G. Fink, Colin; E. Whittaker, Thomas; Santilli, Giorgia; Gissen, Paul; B. Kaufer, Benedikt; Reich, Jana; Andréani, Julien; Simmonds, Peter; K. 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Kuijpers, Taco; van de Kuip, Martijn; Marceline van Furth, A.; Merlijn van den Berg, J.; Biesbroek, Giske; Verkuil, Floris; van der Zee, Carlijn; Pajkrt, Dasja; Boele van Hensbroek, Michaël; Schonenberg, D.; Gruppen, Mariken; Q. Nagelkerke, Sietse; H. Jansen, Machiel; Goetschalckx, Ines; Romani, Lorenza; De Luca, Maia; Chiurchiù, Sara; Di Giuseppe, Martina; L. Vermont, Clementien; A. Moll, Henriëtte; Borensztajn, Dorine; N. Hagedoorn, Nienke; Tan, Chantal; M. 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doi:10.1038/s41586-023-06003-w

Public

Genomic investigations of unexplained acute hepatitis in children

Published in Nature • Mar 30, 2023

Authors:

Sofia Morfopoulou

Sarah Buddle

Oscar Enrique Torres Montaguth

Abstract

. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the li...

Subject

Acute hepatitis

Medicine

Genetics

Research Assistant

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