Genomic investigations of unexplained acute hepatitis in children.

S, Morfopoulou; S, Buddle; Montaguth OE, Torres; L, Atkinson; JA, Guerra-Assunção; Marjaneh M, Moradi; Chiozzi R, Zennezini; N, Storey; L, Campos; JC, Hutchinson; JR, Counsell; G, Pollara; S, Roy; C, Venturini; Diaz JF, Antinao; A, Siam; LJ, Tappouni; Z, Asgarian; J, Ng; KS, Hanlon; A, Lennon; A, McArdle; A, Czap; J, Rosenheim; C, Andrade; G, Anderson; JCD, Lee; R, Williams; CA, Williams; H, Tutill; N, Bayzid; Bernal LM, Martin; H, Macpherson; KA, Montgomery; C, Moore; K, Templeton; C, Neill; M, Holden; R, Gunson; SJ, Shepherd; P, Shah; S, Cooray; M, Voice; M, Steele; C, Fink; TE, Whittaker; G, Santilli; P, Gissen; BB, Kaufer; J, Reich; J, Andreani; P, Simmonds; DK, Alrabiah; S, Castellano; P, Chikowore; M, Odam; T, Rampling; C, Houlihan; K, Hoschler; T, Talts; C, Celma; S, Gonzalez; E, Gallagher; R, Simmons; C, Watson; S, Mandal; M, Zambon; M, Chand; J, Hatcher; S, De; K, Baillie; MG, Semple; J, Martin; I, Ushiro-Lumb; M, Noursadeghi; M, Deheragoda; N, Hadzic; T, Grammatikopoulos; R, Brown; C, Kelgeri; K, Thalassinos; SN, Waddington; TS, Jacques; E, Thomson; M, Levin; JR, Brown; J, Breuer

doi:10.1038/s41586-023-06003-w

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Genomic investigations of unexplained acute hepatitis in children.

Shared by NobleBlocks on Mar 30, 2023 • 12:00 AM UTC

Authors:

Morfopoulou S

Buddle S

Torres Montaguth OE

Abstract

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator particip...

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