Oncogenic signaling is coupled to colorectal cancer cell differentiation state

Sell, Thomas; Klotz, Christian; M. Fischer, Matthias; Astaburuaga-García, Rosario; M. Krug, Susanne; Drost, Jarno; Clevers, Hans; Sers, Christine; Morkel, Markus; Blüthgen, Nils

doi:10.1083/jcb.202204001

Public

Oncogenic signaling is coupled to colorectal cancer cell differentiation state

Published in The Journal of Cell Biology • Mar 18, 2023

Authors:

Thomas Sell

Christian Klotz

Matthias M. Fischer

Abstract

Colorectal cancer progression is intrinsically linked to stepwise deregulation of the intestinal differentiation trajectory. In this process, sequential mutations of APC, KRAS, TP53, and SMAD4 enable oncogenic signaling and establish the hallmarks of cancer. Here, we use mass cytometry of isogenic h...

Subject

Biology

KRAS

Transcriptome

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