The KMT2A recombinome of acute leukemias in 2023

Meyer, Claus; Larghero, Patrizia; A. Lopes, Bruno; Burmeister, Thomas; Gröger, Daniela; Sutton, Rosemary; C. Venn, Nicola; Cazzaniga, Giovanni; Corral Abascal, L; Tsaur, Grigory; Г. Фечина, Л.; Emerenciano, Mariana; S. Pombo‐de‐Oliveira, Maria; Lund-Aho, T; Lundán, Tuija; Montonen, Mirkka; Juvonen, Vesa; Zuna, Jan; Trka, Jan; Ballerini, Paola; Lapillonne, Hélène; H. J. van der Velden, Vincent; Sonneveld, Edwin; Delabesse, Éric; R. Capela de Matos, Roberto; Luiza Macedo Silva, Maria; Bomken, Simon; Katsibardi, K.; Keernik, Maria; Grardel, Nathalie; Mason, Julia; Price, R.; Kim, J.; Eckert, Cornelia; Lo Nigro, Luca; Bueno, Clara; Menéndez, Pablo; zur Stadt, Udo; Gameiro, Paula; Sędek, Łukasz; Szczepański, Tomasz; Bidet, Audrey; Malina -Marcu, Victoria; Shichrur, Keren; Izraeli, Shai; O Madsen, H; W. Schäfer, Beat; Kubetzko, Susanne; Kim, Rathana; Clappier, Emmanuelle; Trautmann, Heiko; Brüggemann, Monika; A. Archer, Paul; Hancock, Jerry; Alten, Julia; Möricke, Anja; Stanulla, Martin; Lentes, Jana; K. Bergmann, Anke; Strehl, Sabine; Köhrer, Stefan; Nebral, Karin; Dworzak, Michael; A. Haas, Oskar; Arfeuille, Chloé; Caye‐Eude, Aurélie; Cavé, Hélène; Marschalek, Rolf

doi:10.1038/s41375-023-01877-1

Public

The KMT2A recombinome of acute leukemias in 2023

Published in Leukemia • Apr 5, 2023

Authors:

Claus Meyer

Patrizia Larghero

Bruno A. Lopes

Abstract

Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the data obtained from 3401 acute leukemia patients that have been analyzed between 2003 and 2022. Genomic breakpoints within t...

Subject

Breakpoint

Chromosomal translocation

Leukemia

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