Efficient Delivery of Biological Cargos into Primary Cells by Electrodeposited Nanoneedles via Cell-Cycle-Dependent Endocytosis

Wang, Zongjie; Wang, Hansen; Lin, Sichun; Labib, Mahmoud; Ahmed, Sharif; Das, Jagotamoy; Angers, Stéphane; H. Sargent, Edward; O. Kelley, Shana

doi:10.1021/acs.nanolett.2c05083

Public

Efficient Delivery of Biological Cargos into Primary Cells by Electrodeposited Nanoneedles via Cell-Cycle-Dependent Endocytosis

Published in Nano Letters • Apr 11, 2023

Authors:

Zongjie Wang

Hansen Wang

Sichun Lin

Abstract

Nanoneedles are a useful tool for delivering exogenous biomolecules to cells. Although therapeutic applications have been explored, the mechanism regarding how cells interact with nanoneedles remains poorly studied. Here, we present a new approach for the generation of nanoneedles, validated their u...

Subject

Endocytosis

Cell biology

Nanotechnology

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