Genomic–transcriptomic evolution in lung cancer and metastasis

Martínez‐Ruiz, Carlos; R. Black, James; Puttick, Clare; S. Hill, Mark; Demeulemeester, Jonas; Larose Cadieux, Elizabeth; Thol, Kerstin; Peter Jones, Thomas; Veeriah, Selvaraju; Naceur‐Lombardelli, Cristina; Toncheva, Antonia; Prymas, Paulina; Rowan, Andrew; Ward, Sophia; Cubitt, Laura; Athanasopoulou, Foteini; Pich, Oriol; Karasaki, Takahiro; A. Moore, David; Salgado, Roberto; Colliver, Emma; Castignani, Carla; Dietzen, Michelle; Huebner, Ariana; Al Bakir, Maise; Tanić, Miljana; B.K. Watkins, Thomas; L. Lim, Emilia; M. Al-Rashed, Ali; Lang, Danny; Clements, James; E. Cook, Daniel; Rosenthal, Rachel; A. Wilson, Gareth; M. Frankell, Alexander; de Carné Trécesson, Sophie; East, Philip; Kanu, Nnennaya; Litchfield, Kevin; J. Birkbak, Nicolai; Hackshaw, Allan; Beck, Stephan; Van Loo, Peter; Jamal‐Hanjani, Mariam; McGranahan, Nicholas; Swanton, Charles; Al Bakir, Maise; L. Lim, Emilia; M. Frankell, Alexander; Litchfield, Kevin; J. Birkbak, Nicolai; Van Loo, Peter; Lester, J.F.; Bajaj, Amrita; Nakas, Apostolos; Sodha-Ramdeen, Azmina; Ang, Keng; Tufail, Mohamad; Fiyaz Chowdhry, Mohammed; Scotland, Molly; Boyles, Rebecca; Rathinam, Sridhar; Wilson, Claire; Marrone, Domenic; Dulloo, Sean; A. Fennell, Dean; Matharu, Gurdeep; Shaw, Jacqui; Riley, Joan; Primrose, Lindsay; Boleti, Ekaterini; Cheyne, Heather; S. Khalil, Mohammed; Richardson, Shirley; Cruickshank, Tracey; Price, Gillian; M. Kerr, Keith; Benafif, Sarah; Gilbert, Kayleigh; Naidu, Babu; J. Patel, Akshay; Osman, Aya; Lacson, Christer; Langman, Gerald; Shackleford, Helen; Djearaman, Madava; Kadiri, Salma; Middleton, Gary; Leek, Angela; Davies Hodgkinson, Jack; Totten, Nicola; Montero, Ángeles; Smith, Elaine; Fontaine, Eustace; Granato, Felice; Doran, Helen; Novasio, Juliette; Rammohan, Kendadai; Dennis Joseph, Leena; Bishop, Paul; Shah, Rajesh; Moss, Stuart; Joshi, Vijay; Crosbie, Philip; Gomes, Fábio; Brown, Kate; Carter, Mathew; Chaturvedi, Anshuman; Priest, Lynsey; Oliveira, Pedro; R. Lindsay, Colin; Blackhall, Fiona; Krebs, Matthew; Summers, Yvonne; Clipson, Alexandra; Tugwood, Jonathan; Kerr, Alastair; G. Rothwell, Dominic; Kilgour, Elaine; Dive, Caroline; J.W.L. Aerts, Hugo; F. Schwarz, Roland; L. Kaufmann, Tom; Szállási, Zoltán; Kisistók, Judit; Sokač, Mateo; Dióssy, Miklós; Bunkum, Abigail; Stewart, Aengus; Magness, Alastair; Karamani, Angeliki; Chain, Benny; Campbell, Brittany; Bailey, Chris; Abbosh, Christopher; E. Weeden, Clare; Lee, Claudia; Richard, Corentin; T. Hiley, Crispin; R. Pearce, David; Karagianni, Despoina; Biswas, Dhruva; Levi, Dina; Hoxha, Elena; Nye, Emma; Grönroos, Eva; Gálvez-Cancino, Felip; Gimeno-Valiente, Francisco; Kassiotis, George; Stavrou, Georgia; Mastrokalos, Gerasimos; Zhai, Hao-Ran; L. Lowe, Helen; Matos, Ignacio; Goldman, Jacki; L. Reading, James; Herrero, Javier; K. Rane, Jayant; Nicod, Jérôme; Min Lam, Jie; A. Hartley, John; S. Peggs, Karl; S.S. Enfield, Katey; Selvaraju, Kayalvizhi; W. Ng, Kevin; Chen, Kezhong; K. Dijkstra, Krijn; Grigoriadis, Kristiana; Thakkar, Krupa; Ensell, Leah; Shah, Mansi; Vasquez Duran, Marcos; Litovchenko, Maria; Werner Sunderland, Mariana; Leung, Michelle; Escudero, Mickael; Angelova, Mihaela; Sivakumar, Monica; Chervova, Olga; Lucas, Olivia; Al‐Sawaf, Othman; Hobson, Philip; Pawlik, Piotr; Stone, Richard; B. Bentham, Robert; E. Hynds, Robert; Vendramin, Roberto; Saghafinia, Sadegh; López, Saioa; Gamble, Samuel; Kuong Anakin Ung, Seng; A. Quezada, Sergio; Vanloo, Sharon; Zaccaria, Simone; Hessey, Sonya; Boeing, Stefan; Kaur Bola, Supreet; Denner, Tamara; Marafioti, Teresa; P. Mourikis, Thanos; J. Spanswick, Victoria; Barbè, Vittorio; Lu, Wei-Ting; Hill, William; Kin Liu, Wing; Wu, Yin; Naito, Yutaka; Ramsden, Zoe; Veiga, Catarina; Royle, Gary; Collins‐Fekete, Charles‐Antoine; Fraioli, Francesco; Ashford, Paul; Clark, Tristan; Förster, Martin; Ming Lee, Siow; Borg, Elaine; Falzon, Mary; Papadatos-Pastos, Dionysis; M. Wilson, James; Ahmad, Tanya; James Procter, Alexander; Ahmed, Asia; N. Taylor, Magali; Nair, Arjun; Lawrence, David; Patrini, Davide; Navani, Neal; M. Thakrar, Ricky; M. Janes, Sam; Martinoni Hoogenboom, Emilie; Monk, Fleur; W. Holding, James; Choudhary, Junaid; Bhakhri, Kunal; Scarci, Marco; Hayward, Martin; Panagiotopoulos, Nikolaos; Gorman, Pat; Khiroya, Reena; Stephens, Robert; Ning Sophia Wong, Yien; Bandula, Steve; Sharp, Abigail; Smith, Sean; Gower, Nicole; Kaur Dhanda, Harjot; S. Chan, Kitty; Pilotti, Camilla; Leslie, Rachel; Grapa, Anca; Zhang, Hanyun; AbdulJabbar, Khalid; Pan, Xiaoxi; Yuan, Yinyin; Chuter, David; MacKenzie, Mairead; Chee, Serena; Alzetani, Aiman; Cave, Judith; Scarlett, Lydia; Richards, Jennifer; Ingram, Papawadee; Austin, Silvia; Lim, Eric; De Sousa, Paulo; Jordan, Simon; Rice, Alexandra; Raubenheimer, Hilgardt; Bhayani, Harshil; Ambrose, Lyn; Devaraj, Anand; Chavan, Hema; Begum, Sofina; Buderi, Silviu; Kaniu, Daniel; Malima, Mpho; Booth, Sarah; G. Nicholson, Andrew; Fernandes, Nadia; Shah, Pratibha; Proli, Chiara; Hewish, Madeleine; Danson, Sarah; Shackcloth, Michael; Robinson, Lily; Russell, Peter; G. Blyth, Kevin; Dick, Craig; Le Quesne, John; Kirk, Alan; Asif, Mo; Bilancia, Rocco; Kostoulas, Nikos; Thomas, Mathew; Swanton, Charles; McGranahan, Nicholas

doi:10.1038/s41586-023-05706-4

Public

Genomic–transcriptomic evolution in lung cancer and metastasis

Published in Nature • Apr 12, 2023

Authors:

Carlos Martínez‐Ruiz

James R. Black

Clare Puttick

Abstract

Abstract Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy 1 . Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcriptomic diversity in 354 non-small cell lung cancer tumours from 347 out of the ...

Subject

Transcriptome

Lung cancer

Metastasis

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