The evolution of lung cancer and impact of subclonal selection in TRACERx

M. Frankell, Alexander; Dietzen, Michelle; Al Bakir, Maise; L. Lim, Emilia; Karasaki, Takahiro; Ward, Sophia; Veeriah, Selvaraju; Colliver, Emma; Huebner, Ariana; Bunkum, Abigail; S. Hill, Mark; Grigoriadis, Kristiana; A. Moore, David; R. Black, James; Kin Liu, Wing; Thol, Kerstin; Pich, Oriol; B.K. Watkins, Thomas; Naceur‐Lombardelli, Cristina; E. Cook, Daniel; Salgado, Roberto; A. Wilson, Gareth; Bailey, Chris; Angelova, Mihaela; B. Bentham, Robert; Martínez‐Ruiz, Carlos; Abbosh, Christopher; G. Nicholson, Andrew; Le Quesne, John; Biswas, Dhruva; Rosenthal, Rachel; Puttick, Clare; Hessey, Sonya; Lee, Claudia; Prymas, Paulina; Toncheva, Antonia; Smith, Jon; Wei, Xing; Nicod, Jérôme; Price, Gillian; M. Kerr, Keith; Naidu, Babu; Middleton, Gary; G. Blyth, Kevin; A. Fennell, Dean; Förster, Martin; Ming Lee, Siow; Falzon, Mary; Hewish, Madeleine; Shackcloth, Michael; Lim, Eric; Benafif, Sarah; Russell, Peter; Boleti, Ekaterini; Krebs, Matthew; Lester, J.F.; Papadatos-Pastos, Dionysis; Ahmad, Tanya; M. Thakrar, Ricky; Lawrence, David; Navani, Neal; M. Janes, Sam; Dive, Caroline; Blackhall, Fiona; Summers, Yvonne; Cave, Judith; Marafioti, Teresa; Herrero, Javier; A. Quezada, Sergio; S. Peggs, Karl; F. Schwarz, Roland; Van Loo, Peter; M. Miedema, Daniël; J. Birkbak, Nicolai; T. Hiley, Crispin; Hackshaw, Allan; Zaccaria, Simone; Le Quesne, John; Van Loo, Peter; Bajaj, Amrita; Nakas, Apostolos; Sodha-Ramdeen, Azmina; Ang, Keng; Tufail, Mohamad; Fiyaz Chowdhry, Mohammed; Scotland, Molly; Boyles, Rebecca; Rathinam, Sridhar; Wilson, Claire; Marrone, Domenic; Dulloo, Sean; Matharu, Gurdeep; Shaw, Jacqui; Riley, Joan; Primrose, Lindsay; Cheyne, Heather; S. Khalil, Mohammed; Richardson, Shirley; Cruickshank, Tracey; Gilbert, Kayleigh; J. Patel, Akshay; Osman, Aya; Lacson, Christer; Langman, Gerald; Shackleford, Helen; Djearaman, Madava; Kadiri, Salma; Leek, Angela; Davies Hodgkinson, Jack; Totten, Nicola; Montero, Ángeles; Smith, Elaine; Fontaine, Eustace; Granato, Felice; Doran, Helen; Novasio, Juliette; Rammohan, Kendadai; Dennis Joseph, Leena; Bishop, Paul; Shah, Rajesh; Moss, Stuart; Joshi, Vijay; Crosbie, Philip; Gomes, Fábio; Brown, Kate; Carter, Mathew; Chaturvedi, Anshuman; Priest, Lynsey; Oliveira, Pedro; R. Lindsay, Colin; Clipson, Alexandra; Tugwood, Jonathan; Kerr, Alastair; G. Rothwell, Dominic; Kilgour, Elaine; J.W.L. Aerts, Hugo; L. Kaufmann, Tom; Szállási, Zoltán; Kisistók, Judit; Sokač, Mateo; Dióssy, Miklós; Demeulemeester, Jonas; Stewart, Aengus; Magness, Alastair; Rowan, Andrew; Karamani, Angeliki; Chain, Benny; Campbell, Brittany; Castignani, Carla; E. Weeden, Clare; Richard, Corentin; R. Pearce, David; Karagianni, Despoina; Levi, Dina; Hoxha, Elena; Larose Cadieux, Elizabeth; Nye, Emma; Grönroos, Eva; Gálvez-Cancino, Felip; Athanasopoulou, Foteini; Gimeno-Valiente, Francisco; Kassiotis, George; Stavrou, Georgia; Mastrokalos, Gerasimos; Zhai, Hao-Ran; L. Lowe, Helen; Matos, Ignacio; Goldman, Jacki; L. Reading, James; K. Rane, Jayant; Min Lam, Jie; A. Hartley, John; S.S. Enfield, Katey; Selvaraju, Kayalvizhi; Litchfield, Kevin; W. Ng, Kevin; Chen, Kezhong; K. Dijkstra, Krijn; Thakkar, Krupa; Ensell, Leah; Shah, Mansi; Vásquez, Marcos; Litovchenko, Maria; Werner Sunderland, Mariana; Leung, Michelle; Escudero, Mickael; Tanić, Miljana; Sivakumar, Monica; Kanu, Nnennaya; Chervova, Olga; Lucas, Olivia; Al‐Sawaf, Othman; Hobson, Philip; Pawlik, Piotr; Stone, Richard; E. Hynds, Robert; Vendramin, Roberto; Saghafinia, Sadegh; López, Saioa; Gamble, Samuel; Kuong Anakin Ung, Seng; Vanloo, Sharon; Boeing, Stefan; Beck, Stephan; Kaur Bola, Supreet; Denner, Tamara; P. Mourikis, Thanos; J. Spanswick, Victoria; Barbè, Vittorio; Lu, Wei-Ting; Hill, William; Wu, Yin; Naito, Yutaka; Ramsden, Zoe; Veiga, Catarina; Royle, Gary; Collins‐Fekete, Charles‐Antoine; Fraioli, Francesco; Ashford, Paul; Clark, Tristan; Borg, Elaine; M. Wilson, James; James Procter, Alexander; Ahmed, Asia; N. Taylor, Magali; Nair, Arjun; Patrini, Davide; Martinoni Hoogenboom, Emilie; Monk, Fleur; W. Holding, James; Choudhary, Junaid; Bhakhri, Kunal; Scarci, Marco; Hayward, Martin; Panagiotopoulos, Nikolaos; Gorman, Pat; Khiroya, Reena; Stephens, Robert; Ning Sophia Wong, Yien; Bandula, Steve; Sharp, Abigail; Smith, Sean; Gower, Nicole; Kaur Dhanda, Harjot; S. Chan, Kitty; Pilotti, Camilla; Leslie, Rachel; Grapa, Anca; Zhang, Hanyun; AbdulJabbar, Khalid; Pan, Xiaoxi; Yuan, Yinyin; Chuter, David; MacKenzie, Mairead; Chee, Serena; Alzetani, Aiman; Scarlett, Lydia; Richards, Jennifer; Ingram, Papawadee; Austin, Silvia; De Sousa, Paulo; Jordan, Simon; Rice, Alexandra; Raubenheimer, Hilgardt; Bhayani, Harshil; Ambrose, Lyn; Devaraj, Anand; Chavan, Hema; Begum, Sofina; Buderi, Silviu; Kaniu, Daniel; Malima, Mpho; Booth, Sarah; Fernandes, Nadia; Shah, Pratibha; Proli, Chiara; Danson, Sarah; Robinson, Lily; Dick, Craig; Kirk, Alan; Asif, Mo; Bilancia, Rocco; Kostoulas, Nikos; Thomas, Mathew; Jamal‐Hanjani, Mariam; McGranahan, Nicholas; Swanton, Charles

doi:10.1038/s41586-023-05783-5

Public

The evolution of lung cancer and impact of subclonal selection in TRACERx

Published in Nature • Apr 12, 2023

Authors:

Alexander M. Frankell

Michelle Dietzen

Maise Al Bakir

Abstract

. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher lung cancer evolution and address the primary study endpoint: determining the relati...

Subject

Selection (genetic algorithm)

Cancer

Lung cancer

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