AKT activity orchestrates marginal zone B cell development in mice and humans

Cox, Eva-Maria; El Behi, Mohamed; Ries, Stefanie; F. Vogt, Johannes; Kohlhaas, Vivien; Michna, Thomas; Manfroi, Benoît; Al-Maarri, Mona; Wanke, Florian; Tirosh, Boaz; Pondarré, Corinne; Lezeau, Harry; Yogev, Nir; Mittenzwei, Romy; Descatoire, Marc; Weller, Sandra; Weill, Jean–Claude; Reynaud, Claude–Agnès; Boudinot, Pierre; Jouneau, Luc; Tenzer, Stefan; Distler, Ute; Rensing‐Ehl, Anne; König, Christoph; Staniek, Julian; Rizzi, Marta; Magérus, Aude; Rieux‐Laucat, Frédéric; Thomas Wunderlich, F.; Hövelmeyer, Nadine; Fillatreau, Simon

doi:10.1016/j.celrep.2023.112378

Public

AKT activity orchestrates marginal zone B cell development in mice and humans

Published in Cell Reports • Apr 1, 2023

Authors:

Eva-Maria Cox

Mohamed El Behi

Stefanie Ries

Abstract

The signals controlling marginal zone (MZ) and follicular (FO) B cell development remain incompletely understood. Here, we show that AKT orchestrates MZ B cell formation in mice and humans. Genetic models that increase AKT signaling in B cells or abolish its impact on FoxO transcription factors high...

Subject

Immunoglobulin D

Protein kinase B

Marginal zone

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