BBB opening with focused ultrasound in nonhuman primates and Parkinson’s disease patients: Targeted AAV vector delivery and PET imaging

Blesa, Javier; A. Pineda‐Pardo, José; Inoue, Ken‐ichi; Gasca‐Salas, Carmen; Balzano, Tiziano; López‐González del Rey, Natalia; Reinares-Sebastián, Alejandro; Esteban-García, Noelia; Rodríguez‐Rojas, Rafael; Pérez Márquez, Raquel; Ciorraga, María; del Álamo, Marta; García‐Cañamaque, Lina; Ruiz de Aguiar, Santiago; Rachmilevitch, Itay; Trigo‐Damas, Inés; Takada, Masahiko; Á. Obeso, José

doi:10.1126/sciadv.adf4888

Public

BBB opening with focused ultrasound in nonhuman primates and Parkinson’s disease patients: Targeted AAV vector delivery and PET imaging

Published in Science Advances • Apr 19, 2023

Authors:

Javier Blesa

José A. Pineda‐Pardo

Ken‐ichi Inoue

Abstract

Intracerebral vector delivery in nonhuman primates has been a major challenge. We report successful blood-brain barrier opening and focal delivery of adeno-associated virus serotype 9 vectors into brain regions involved in Parkinson’s disease using low-intensity focus ultrasound in adult macaque mon...

Subject

Magnetic resonance imaging

Blood–brain barrier

Medicine

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