Integrating gene annotation with orthology inference at scale.

M Kirilenko, Bogdan; Munegowda, Chetan; Osipova, Ekaterina; Jebb, David; Sharma, Virag; Blumer, Moritz; E Morales, Ariadna; Ahmed, Alexis-Walid; Kontopoulos, Dimitrios-Georgios; Hilgers, Leon; Lindblad-Toh, Kerstin; K Karlsson, Elinor; Consortium‡, Zoonomia; Hiller, Michael

doi:10.1126/science.abn3107

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Integrating gene annotation with orthology inference at scale.

Shared by NobleBlocks on Apr 28, 2023 • 12:00 AM UTC

Authors:

Bogdan M Kirilenko

Chetan Munegowda

Ekaterina Osipova

Abstract

Annotating coding genes and inferring orthologs are two classical challenges in genomics and evolutionary biology that have traditionally been approached separately, limiting scalability. We present TOGA (Tool to infer Orthologs from Genome Alignments), a method that integrates structural gene annot...

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