Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

D. Healy, Michael; E. McNally, Kerrie; Butkovič, Rebeka; Chilton, Molly; Kato, Kohji; Sacharz, Joanna; McConville, Calum; R. R. Moody, Edmund; Shaw, Shrestha; J. Planelles-Herrero, Vicente; K.N. Yadav, Sathish; Ross, Jennifer; Borucu, Ufuk; S. Palmer, Catherine; Chen, Kai‐En; I. Croll, Tristan; J. Hall, Ryan; J. Caruana, Nikeisha; Ghai, Rajesh; H.D. Nguyen, Thi; J. Heesom, Kate; Saitoh, Shinji; Berger, Imre; Schaffitzel, Christiane; A. Williams, Tom; A. Stroud, David; Derivery, Emmanuel; M. Collins, Brett; J. Cullen, Peter

doi:10.1016/j.cell.2023.04.003

Public

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

Published in Cell • May 1, 2023

Authors:

Michael D. Healy

Kerrie E. McNally

Rebeka Butkovič

Abstract

The Commander complex is required for endosomal recycling of diverse transmembrane cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies: Retriever composed of VPS35L, VPS26C, and VPS29; and the CCC complex which contains twelve subunits: COMMD1-COMMD10 and the coiled-...

Subject

Biology

Endosome

Cell biology

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