Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study

Xu, Shu; Li, Xiaozhi; Zhang, Shenghong; Qi, Cancan; Zhang, Zhenhua; Ma, Ruiqi; Xiang, Liyuan; Chen, Lianmin; Zhu, Yijun; Tang, Ce; R. Bourgonje, Arno; Li, Miaoxin; He, Yao; Zeng, Zhirong; Hu, Shixian; Feng, Rui; Chen, Minhu

doi:10.1186/s12916-023-02878-8

Public

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study

Published in BMC Medicine • May 11, 2023

Authors:

Shu Xu

Xiaozhi Li

Shenghong Zhang

Abstract

BACKGROUND: Oxidative stress (OS) is a key pathophysiological mechanism in Crohn's disease (CD). OS-related genes can be affected by environmental factors, intestinal inflammation, gut microbiota, and epigenetic changes. However, the role of OS as a potential CD etiological factor or triggering fact...

Subject

Mendelian randomization

DNA methylation

Epigenetics

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