The single-cell and spatial transcriptional landscape of human gastrulation and early brain development

Zeng, Bo; Liu, Zeyuan; Lu, Yufeng; Zhong, Suijuan; Qin, Shenyue; Huang, Luwei; Zeng, Yang; Li, Zixiao; Dong, Hao; Shi, Yingchao; Yang, Jialei; Dai, Yalun; Ma, Qiang; Sun, Le; Bian, Lihong; Han, Dan; Chen, Youqiao; Qiu, Xin; Wang, Wei; Marín, Óscar; Wu, Qian; Wang, Yongjun; Wang, Xiaoqun

doi:10.1016/j.stem.2023.04.016

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The single-cell and spatial transcriptional landscape of human gastrulation and early brain development

Published in Cell stem cell • May 15, 2023

Authors:

Bo Zeng

Zeyuan Liu

Yufeng Lu

Abstract

The emergence of the three germ layers and the lineage-specific precursor cells orchestrating organogenesis represent fundamental milestones during early embryonic development. We analyzed the transcriptional profiles of over 400,000 cells from 14 human samples collected from post-conceptional weeks...

Subject

Biology

Gastrulation

Cell biology

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