Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation

Wang, Kaiyuan; Li, Yang; Wang, Xia; Zhang, Zhijun; Cao, Liping; Fan, Xiaoyuan; Wan, Bin; Liu, Fengxiang; Zhang, Xuanbo; He, Zhonggui; Zhou, Yingtang; Wang, Dong; Sun, Jin; Chen, Xiaoyuan

doi:10.1038/s41467-023-38601-7

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Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation

Published in Nature Communications • May 23, 2023

Authors:

Kaiyuan Wang

Yang Li

Xia Wang

Abstract

Abstract The immunologically “cold” microenvironment of triple negative breast cancer results in resistance to current immunotherapy. Here, we reveal the immunoadjuvant property of gas therapy with cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway activation to augment aggr...

Subject

Sting

Cancer research

Chemistry

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