The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

Ma, Lu; Hu, Xin; Song, Lili; Chen, Xiaoying; Ouyang, Menglu; Billot, Laurent; Li, Qiang; Malavera, Alejandra; Li, Xi; Muñoz Venturelli, Paula; de Silva, Asita; Huy Thang, Nguyen; Wahab, Kolawole; Pandian, Jeyaraj; Wasay, Mohammad; Marques Pontes‐Neto, Octávio; Abanto, Carlos; Araúz, Antonio; Shi, Haiping; Tang, Guanghai; Zhu, Sheng; She, Xiaochun; Liu, Leibo; Sakamoto, Yuki; You, Shoujiang; Han, Qiao; Crutzen, Bernard; Cheung, Emily; Li, Yunke; Wang, Xia; Chen, Chen; Liu, Feifeng; Zhao, Yang; Li, Hao; Liu, Yi; Jiang, Yan; Chen, Lei; Wu, Bo; Liu, Ming; Xu, Jianguo; You, Chao; M Anderson, C; Robinson, Thompson; Jaime Miranda, J.; S. Anderson, Craig; You, Chao; Song, Lili; Parry‐Jones, Adrian; Sprigg, Nikola; F. Durrans, S.; Harris, Caroline; Bamford, Ann; Smith, Olivia; J. Herbert, Robert; Chen, Christopher; Whiteley, William; Hu, Rong; Billot, Laurent; Li, Qiang; Mysore, Jayanthi; Hu, Xin; Zhang, Yao; Liu, Feifeng; Sakamoto, Yuki; You, Shoujiang; Han, Qiao; Crutzen, Bernard; Li, Yunke; Cheung, Emily; Jan, Stephen; Liu, Hueiming; Ouyang, Menglu; Sun, Lingli; Chu, Honglin; Anjum, Anila; Gonzalez Mc Cawley, Francisca; Del Río, Alejandra; Rimoli, Bruna; Cerantola, Rodrigo; Jeevarajah, Thanushanthan; Kannangara, Madhushani; Joseph, Andrene; Nanayakkara, Chamath; Chen, Xiaoying; Malavera, Alejandra; Zhang, Chunmiao; Yang, Zhao; Li, Brook; Meng, Zhuo; Ouyang, Menglu; Liu, Leibo; Ning, Yi; Dong, Le; Armenis, Manuela; Lim, Joyce; Monaghan, Helen; Ma, Lu; Hu, Xin; Li, Zhiheng; Luo, Rui; Cheng, Guojuan; Dong, Yilin; Liu, Ziqin; Wang, Shuihong; Zhang, Ying; Cheng, J.P.; Shi, Hui; Li, Wenjing; Mou, Langming; Yi, Ping; Chen, Chen; Xg, Chen; Weerawardena, Shalomi; Ellawala, Poornima; Ranasinghe, Enalee; Rodrigo, Chrishmi; Wahab, Kolawala; Adeniyi, Sunday; Pandian, Jeyaraj; Khanna, Megha; Muñoz Venturelli, Paula; González, Francisca; Urrutia Goldsack, Francisca; Wasay, Mohammad; Begum, Dilshad; Anjum, Anila; Marques Pontes‐Neto, Octávio; Rodrigues Camilo, Millene; Antunes Dias, Francisco; Vincenzi, Octavio; Cerantola, Rodrigo; Heloísa Cabral Moro, Carla; Santos, Renata; Texeira, Nara; Luiz Longo, Alexandre; Liberato, R.; Cristina Ouriques Martins, Sheila; Pille, Arthur; Cristine Chwal, Bruna; Silva, Isabel; Titton, N.F.; Weiss, Gustavo; Mora, Daissy; Ouriques, Magda; Augusto Carbonera, Leonardo; Bazán, Rodrigo; Pinheiro Módolo, Gabriel; Cristina Winckler, Fernanda; Miranda, Luana; Thomaz de Souza, Juli; Rojo, Alexis; Uslar, Wilhelm; Medel, Lorena; López, Javiera; Herrero, D.; M. Lavados, Pablo; Vargas Latorre, Barbara; Conejan, Nathalie; Esparza, Tomás; Sotomayor, Patricio; Wenger, Denisse; Pablo Gigoux, Juan; Letelier, Aldo; Acevedo, Lilian; Moya, Vivianne; Figueroa, Cristian; Vallejos, N.; Conejan, Nathalie; Esparza, Tomás; Sotomayor, Patricio; Guerrero, Rodrigo; Velásquez, Mauricio; Vallejos, José; Pallauta, Kimerly; Santibanez, Tamara; Queirolo, Angelo; Lobos, A.-T.; Jiang, Yongming; Li, Weimin; Huang, Wei; Luo, Ke; Liu, Gangying; Tang, Guanghai; Yang, Guang; Jiang, Hongtao; Zhang, Xu; Jing, Hongyan; Zhu, Sheng; Pu, Bo; Lv, Dong; Kang, Hui; Hu, Qiuping; She, Xiaochun; Jiang, Xiaoming; Chen, Yanli; Yang, Shenghua; He, Jianjun; Li, Zongping; Cheng, Gang; Huang, Hailin; Wang, Xiaoyi; Lin, Jianqiong; Chen, Minhui; Yang, Chenghao; Ding, Hao; Deng, Yunliang; Luo, Fei; Zhang, Rongjun; Wang, Xiaofeng; Zhang, Hongbing; Yang, Xiaoliang; Zhang, Yang; Yang, Chengyi; He, Yu; Liu, Feng; Wang, Rongjie; Zhang, Yuhui; Xin, Xiaodong; Feng, Bin; Hao, Wanru; Eun Song, Chang; Guo, Yun; Jiang, Dehua; Chen, Jie; Tang, Changtong; Zhu, Hongliang; Li, Xin; Cui, Jin; Xu, Haidong; Li, Boyang; Tang, Fusheng; Li, Yuanbin; Gao, Min; Yang, Bo; Xu, Xuejun; Deng, Bing; Zheng, Yi; Ge, Yuanhong; Chen, Keyu; Liu, Yang; Li, Xinshen; Zhong, Tingting; Xu, Jianfeng; Zhang, Hai; Wang, Jiyue; Zhu, Jian‐Xin; Sun, Hanyu; Fu-hua, YU; Zhang, Xueguang; You, Chao; Ma, Lu; Hu, Xin; Xu, Jianguo; Li, Zhiheng; Mingsen, Zhang; Wang, Bin; Ma, Yiming; Jiang, Donglin; Zhou, Jun; Liu, Cong; Nie, Wenhong; Li, Mingguo; Tian, Tao; Li, Y; He, Mingfang; Tu, Xiaolong; Wu, Zhengjun; Liu, Hong; Zhong, Dongsheng; Jiang, Rongcai; Sun, Jian; Tian, Ye; Wei, Yingsheng; An, Shuo; Wei, Pingbo; Luo, Le; Lin, Bin; Liu, Gang; Wen, Yan; Cai, Qiang; Chen, Qianxue; Pan, Lei; Li, Zhiyang; Zhang, Meifang; He, Jiaquan; Chen, Yan; Liu, Jun; Liu, Xing‐Hai; Li, Junyan; Chen, Min; Wang, Jing; Zhou, Bingzhi; Ye, Baichun; Zhang, Jiancheng; Zhang, Manyuan; Pan, Xuming; Yu, Xiaoxiang; Xu, Jian; Xiao, Qingbao; Wang, Yuefei; Tao, Liang; Lin, Shi; Zheng, Niandong; You, Guoliang; Lei, Bo; Chen, Shu; Wu, Honggang; Jin, Hu; Zhao, Jian‐Lan; Yu, Jian; Yuan, Qiang; Du, Zhuoying; Tang, Xielin; Li, Qianke; Liu, Shenghua; Yang, Feilong; Xiao, Kui; Luo, Chao; Wang, Guang; Che, Xudong; Teng, Zhipeng; Wan, Wenwu; Li, Jun; Liu, Yu; Fan, Mingbo; Zhang, Tao; Cai, Lun; Ma, Yuan; Ma, Zhifeng; Li, Bin; He, Linlin; Li, Jinghui; Zhang, Weibing; Zhang, Shuxin; Zhang, Hongzhen; Dai, Yingguang; Lei, Jun; Mao, Lei; Huang, Yiyang; Zhou, Zhi; Chen, Ping; Chen, Fang; Pan, Wei; Li, Tiangui; Chen, Honglin; Zeng, Mengfei; Mou, Kejie; Xue, Jun; Jiang, Yong; Tang, Xiaoping; Chen, Tao; Zhang, Yalan; Xu, Yanbing; Gu, Yuchen; Chen, Lei; Zhao, Yu‐Jun; Yang, Bin; Kuai, Peng; Wang, Xi; Yang, Yuwang; Hu, Xueling; Zhang, Huitian; Yang, Yintao; Wang, Weifeng; Zhang, Junyi; Cheng, Wei; Zhang, Xiaoxue; Ma, Xiaowen; He, Qin; Zhang, Li; Gao, Rong; Liu, Huixiang; Ye, Jingwei; Xu, Ping; Wu, Xin; Yuan, Yuan; Zou, Peng; Zhang, Zhen; Cheng, Jiyong; Zhou, Zhangming; Zeng, Yijun; Zhang, Liang; Du, Deming; Yu, Shui; Cao, Yongjun; You, Shoujiang; Xu, Jiaping; Huang, Zhichao; Chen, Dongqin; Xiao, Wenfeng; Zhu, Li; Miao, Yuan; Wang, Yuhai; Shi, Dongliang; Hu, Xu; Xiang, Dingchao; Shi, Like; Wang, Hong‐Qin; Yang, Liu; Wang, Miao; Hu, Yiyi; Zhao, Yuchun; Hu, Xi; Liu, Yang; Zhou, Weiduo; Sun, Chao; Chen, Tao; Tang, Dong; Yao, Kun; Jong You, Jin; Chen, Shishi; Yao, Jian-min; Li, Huanmei; Liu, Jinmei; Bai, Ailin; Yi, Yong; Deng, Qingshan; Luo, Peng; Wang, Han; Jiang, Jingcheng; Yang, Qingwei; He, Shunpo; Wang, Jun; Chen, Yu; He, Hua; Deng, Yuyang; Cao, Zhikai; Yi, Xuxia; Luo, Jinbiao; Luo, Shuang; Gong, Min; Liu, Li; Gao, Xuejun; Liu, Jia‐Bao; Wu, Lie; Zhang, Jia; Sun, Hongying; Li, Xinhui; Lu, Jia; Wu, Jianbing; Zhang, Jie; Zhang, Huajun; Du, Chunfu; Li, Shun; Yang, Xiaobin; He, Jie; Liao, Lei; Zhou, Gezhi; Dong, Wentao; Chen, Yunxiang; Lin, Xiaofeng; Shui, Xujian; Zhang, Peng; Zhao, Yuan; Yang, Hongli; Zhao, Wenbin; Zhang, Xiaoyi; Chen, Jincao; Wu, Qian; Dai, Xuan; Tang, Baogui; Wang, Yinjuan; Liu, Tao; Zhang, Haixia; Duan, Faliang; Luo, Ming; Jiao, Qing-fang; Lei, Guoliang; Wang, Dong; Song, Chunwang; Tan, Haopeng; Ye, Feng; Qin, Xinghu; Liang, Xiaolong; Liu, J.; Yang, Lang; Yang, Jie; Lin, Yapeng; Yang, Qian; Ma, Xuntai; Qi, Yinkuang; Pan, Baogen; Jiang, Caixia; Ye, Zhanying; Dong, Ce; Yue, Xiongfei; Yang, Xiaopeng; Maimaitiyiming, Tuoheti; Dong, Jun; Yonggang, Wu; Gao, Feng; Zhao, Deqiang; Zhang, Xinghai; Wang, PengJun; Jiang, Hongbo; Li, Jianping; Zhang, Wei; Chen, Jing; Tong, Haibo; Wang, Yonghong; Qiao, Kaipeng; Guo, Fuyou; Zhang, Mingchu; Hu, Yan; Feng, Mengzhao; Song, Dengpan; Zuo, Yi; Chen, Shangjun; Qian, Chao; Li, Baoming; Ma, Jingku; Zhang, Sunfu; Kong, Bin; Dong, Xingyu; Li, Qiang; Fang, Sheng; Lü, Bin; Li, Yang; Zhang, Zhen; Yang, Yongling; Hong, Yu; Sun, Huaiyu; Wang, Yue; Wang, Weimin; Li, Tong; Li, Shengli; Xu, Zhiming; Wang, Yongyi; Dong, Qiang; Tang, Yuping; Chu, Heling; Lü, Ying; Wang, Zhong; Sun, Xiaoou; Zhao, Jianhua; Yang, Shuaifeng; Qian, Xiying; Onkarappa Saroja, Aralikatte; Naik k, Ravishankar; Chindhi, Sandip; Pampaniya, Nakul; Amaresh, Kurubara; Iype, Thomas; Dileep, R; Rajan, Reeja; Panicker, Praveen; Das, Rupjyoti; Choudhury, Nupur; Gohain, P.; Webster, Jemin; Pakma, Biyol; Sangi, Lalbiak; Sebastian, Ivy; Aggrawal, Gaurav; Raj, Komal; Rajoura, Deepankshi; Singh, Sulena; Aggrawal, Varun; Narang, Amit; Araúz, Antonio; Cano-Nigenda, Vanesa; López-Mena, Diego; Eduardo Valdéz-Ruvalcaba, Héctor; Toledo-Treviño, Roberto; Obiako, Reginald; Abubakar, Sani; Emeka, Oguike; Balogun, Olayemi; Lois, Melika; Philip, Ibinaiye; Comfort O, Olurishe; Okubadejo, Njideka; Agabi, Osigwe; O. Ojo, Oluwadamilola; Wahab, Kolawole; Bello, Abiodun; Ibukun, Oyinloye; Sanayaolu, Olufemi; Adeniyi, Sunday; Jimoh, Abdulraheem; Wasay, Mohammad; Begum, Dilshad; Anjum, Anila; Waheed, Shahid; Kamal, Dr.Ayeesha; Farhat Shoaib, Raja; Orooj, Fizza; Majid, Sadaf; Zehra, Taskeen; Salam Khan, Abdus; Shanker, Ravi; Ali Syed, Nadir; Ahmad, Nashwa; Abanto, Carlos; P. Valencia, Ana; Barrientos, Danny; Ramirez, Jorge; Fernández–Calle, Pilar; Palliyeguruge, Dilum; Muthucumarana, Sumudu; Ratnayaka, Shiroma; Ganihiarachchi, Dilhara; Bandaranayake, Arundathi; Somaratne, Seneviratnage; Narayana, Saumya; Gallage, Sithara; Senanayake, Bimsara; Samarasiri, Udari; Luke, Dunya; Sivapathasundaram, Mythily; Sahadevan, Vithoosan; Rasmi, Amani; Deshaka, Yuran; Fernando, Nilukshi; Munasinghe, Aruna; Rathnapriya, Kapilanga; Nissanka, A.S; T. G. S. Karunathilake, K.; Gayan, Isuru; Wijenayake, Kaminda; Gunasekara, H.D.D.C.; Vidyarathne, Jagath; Keshavaraj, Ajantha; Janarthanan, Kanagasabapathy; Gerald Jeevathasan, Arhivalaky; Sivamainthan, Sivaram; John Priyanth, Mathyamuthan; John Priyanth, Abirami; Rajendiran, Thambippillai; Alwis, Sanjeewa; Gunasekare, Nushara; Liyanarachchi, Vasundara; Dissanayake, Athula; Uluwattage, W.; Ratnayake, G.; Rajinee, Charika; Jayawardana, S.; B Peiris, J; Wicramasinghe, Ranjith; Fernando, Chamila; Abbas, Jessie; Withanage, Nethmini; Bandara, Makaranda; Ton, Duy; Chi Nguyen, Van; Phương Đào, Viet; Trung Vuong, Xuan; Tn, Nguyen; Hieu Dinh, Trung; Quan Phan, Ha; Bui, Q.; Tho Phung, Dinh; Pham, Quang; Pham, D.; Thuan, Duc; Duc Dang, Phuc; Duc Dang, Minh; Hai Nguyen, Dang; Phuong Nga Nguyen, Thi; Huy Nguyen, Quoc; Dai Pham, Quoc; Vinh Chau, Quoc; Thy Van Tai, Vinh; Vinh Le, Tran; Tri Le, Cong; Mai Khuong Tran, Ha; Khanh Nguyen, Huu; Minh Thao Ngyen, Hoang; Chien Vo, Duc; My Phuong Nguyen, Thai; Thanh Tran, Trung; Hanh Vi Vo, Thi; Nhien Cao, Hao; Thang Nguyen, Ba; Le, T.; Duc La, Thien; Duc Pham, Chi; Thai, Huy

doi:10.1016/s0140-6736(23)00806-1

Public

The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial

Published in The Lancet • May 25, 2023

Authors:

Lu Ma

Xin Hu

Lili Song

Abstract

BACKGROUND: Early control of elevated blood pressure is the most promising treatment for acute intracerebral haemorrhage. We aimed to establish whether implementing a goal-directed care bundle incorporating protocols for early intensive blood pressure lowering and management algorithms for hyperglyc...

Subject

Medicine

Randomized controlled trial

Emergency medicine

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!