The landscape of tolerated genetic variation in humans and primates

Gao, Hong; Hamp, Tobias; M. Ede, Jeffrey; G. Schraiber, Joshua; F. McRae, Jeremy; Singer‐Berk, Moriel; Yang, Yanshen; S. D. Dietrich, Anastasia; Fiziev, Petko; F. K. Kuderna, Lukas; Sundaram, Laksshman; Wu, Yibing; N. Adhikari, Aashish; Field, Yair; Chen, Chen; Batzoglou, Serafim; Aguet, François; Lemire, Gabrielle; Reimers, Rebecca; J. Balick, Daniel; C. Janiak, Mareike; Kuhlwilm, Martin; D. Orkin, Joseph; Manu, Shivakumara; Valenzuela, Alejandro; Bergman, Juraj; Rousselle, Marjolaine; Ennes Silva, Felipe; Águeda, Lídia; Blanc, Julie; Gut, Marta; de Vries, Dorien; Goodhead, Ian; Alan Harris, R.; Raveendran, Muthuswamy; Jensen, Axel; S. Chuma, Idriss; E. Horvath, Julie; Hvilsom, Christina; Juan, David; Frandsen, Peter; Rodrigues de Melo, Fabiano; Bertuol, Fabrício; Byrne, Hazel; Sampaio, Iracilda; Pires Farias, Izeni; Valsecchi, João; Rezende Messias, Mariluce; Nazareth Ferreira da Silva, Maria; Trivedi, Mihir; Vieira Rossi, Rogério; Hrbek, Tomas; Andriaholinirina, Nicole; Rabarivola, C.; Zaramody, Alphonse; J. Jolly, Clifford; E. Phillips‐Conroy, Jane; K. Wilkerson, Gregory; R. Abee, Christian; H. Simmons, Joe; Fernández‐Duque, Eduardo; Kanthaswamy, Sree; Shiferaw, Fekadu; Wu, Dong‐Dong; Zhou, Long; Shao, Yong; Zhang, Guojie; D. Keyyu, Julius; Knauf, Sascha; Đức Lê, Minh; Lizano, Esther; Merker, Stefan; Navarro, Arcadi; Bataillon, Thomas; Nadler, Tilo; Chuen Khor, Chiea; Lee, Jessica; Tan, Patrick; Khong Lim, Weng; C. Kitchener, Andrew; Zinner, Dietmar; Gut, Marta; Melin, Amanda; Guschanski, Katerina; Heide Schierup, Mikkel; M. D. Beck, Robin; Umapathy, Govindhaswamy; Roos, Christian; P. Boubli, Jean; Lek, Monkol; Sunyaev, Shamil; O’Donnell‐Luria, Anne; L. Rehm, Heidi; Xu, Jinbo; Rogers, Jeffrey; Marquès‐Bonet, Tomàs; Kai‐How Farh, Kyle

doi:10.1126/science.abn8197

Public

The landscape of tolerated genetic variation in humans and primates

Published in Science • Jun 1, 2023

Authors:

Hong Gao

Tobias Hamp

Jeffrey M. Ede

Abstract

Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtained whole-genome sequencing data for 809 individual...

Subject

Biology

Genetic variation

Genome

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!