Preoperative Treatment of Locally Advanced Rectal Cancer

Schrag, Deborah; Shi, Qian; R. Weiser, Martin; J. Gollub, Marc; B. Saltz, Leonard; Musher, Benjamin; E. Goldberg, Joel; Al Baghdadi, Tareq; A. Goodman, Karyn; R. McWilliams, Robert; M. Farma, Jeffrey; J. George, Thomas; F. Kennecke, Hagen; Shergill, Ardaman; Montemurro, Michael; D. Nelson, Garth; Colgrove, Brian; Gordon, Vallerie; P. Venook, Alan; M. O’Reilly, Eileen; A. Meyerhardt, Jeffrey; C. Dueck, Amylou; Basch, Ethan; J. Chang, George; J. Mamon, Harvey

doi:10.1056/nejmoa2303269

Public

Preoperative Treatment of Locally Advanced Rectal Cancer

Published in New England Journal of Medicine • Jun 4, 2023

Authors:

Deborah Schrag

Qian Shi

Martin R. Weiser

Abstract

BACKGROUND: Pelvic radiation plus sensitizing chemotherapy with a fluoropyrimidine (chemoradiotherapy) before surgery is standard care for locally advanced rectal cancer in North America. Whether neoadjuvant chemotherapy with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) can be used in lieu of ...

Subject

FOLFOX

Medicine

Hazard ratio

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