Taurine deficiency as a driver of aging.

Parminder, Singh,; Kishore, Gollapalli,; Stefano, Mangiola,; Daniela, Schranner,; Mohd Aslam, Yusuf,; Manish, Chamoli,; Sting L, Shi,; Bastos, Bruno, Lopes; Tripti, Nair,; Annett, Riermeier,; Elena M, Vayndorf,; Judy Z, Wu,; Aishwarya, Nilakhe,; Christina Q, Nguyen,; Michael, Muir,; Michael G, Kiflezghi,; Anna, Foulger,; Alex, Junker,; Jack, Devine,; Kunal, Sharan,; Shankar J, Chinta,; Swati, Rajput,; Anand, Rane,; Philipp, Baumert,; Martin, Schönfelder,; Francescopaolo, Iavarone,; Lorenzo, Giorgia, di; Swati, Kumari,; Alka, Gupta,; Rajesh, Sarkar,; Costerwell, Khyriem,; Amanpreet S, Chawla,; Ankur, Sharma,; Nazan, Sarper,; Naibedya, Chattopadhyay,; Bichitra K, Biswal,; Carmine, Settembre,; Perumal, Nagarajan,; Kimara L, Targoff,; Martin, Picard,; Sarika, Gupta,; Vidya, Velagapudi,; Anthony T, Papenfuss,; Alaattin, Kaya,; Miguel Godinho, Ferreira,; Brian K, Kennedy,; Julie K, Andersen,; Gordon J, Lithgow,; Abdullah Mahmood, Ali,; Arnab, Mukhopadhyay,

doi:10.1126/science.abn9257

Public

Taurine deficiency as a driver of aging.

Published in Science (New York, N.Y.) • Jun 9, 2023

Authors:

Singh, Parminder

Gollapalli, Kishore

Mangiola, Stefano

Abstract

Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the p...

Subject

Animals

Humans

Mice

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