Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon‐derived peptides

Ueno, Shinji; Seino, Yusuke; Hidaka, Shihomi; Nakatani, Masashi; Hitachi, Keisuke; Murao, Naoya; Maeda, Yasuhiro; Fujisawa, Haruki; Shibata, Megumi; Takayanagi, Takeshi; Iizuka, Katsumi; Yabe, Daisuke; Sugimura, Yoshihisa; Tsuchida, Kunihiro; Hayashi, Yoshitaka; Suzuki, Atsushi

doi:10.1111/jdi.14032

Public

Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon‐derived peptides

Shared by NobleBlocks on Jun 9, 2023 • 12:00 AM UTC

Authors:

Shinji Ueno

Yusuke Seino

Shihomi Hidaka

Abstract

ABSTRACT Aims/Introduction Glucagon is secreted from pancreatic α‐cells and plays an important role in amino acid metabolism in liver. Various animal models deficient in glucagon action show hyper‐amino acidemia and α‐cell hyperplasia, indicating that glucagon contributes to feedback regulation betw...

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