Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon‐derived peptides

Ueno, Shinji; Seino, Yusuke; Hidaka, Shihomi; Nakatani, Masashi; Hitachi, Keisuke; Murao, Naoya; Maeda, Yasuhiro; Fujisawa, Haruki; Shibata, Megumi; TAKAYANAGI, Takeshi; Iizuka, Katsumi; Yabe, Daisuke; Sugimura, Yoshihisa; Tsuchida, Kunihiro; Hayashi, Yoshitaka; Suzuki, Atsushi

doi:10.1111/jdi.14032

Public

Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon‐derived peptides

Published in Journal of Diabetes Investigation • Jun 9, 2023

Authors:

Shinji Ueno

Yusuke Seino

Shihomi Hidaka

Abstract

AIMS/INTRODUCTION: Glucagon is secreted from pancreatic α-cells and plays an important role in amino acid metabolism in liver. Various animal models deficient in glucagon action show hyper-amino acidemia and α-cell hyperplasia, indicating that glucagon contributes to feedback regulation between the ...

Subject

Internal medicine

Endocrinology

Skeletal muscle

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