Glucosylceramide Synthase Inhibitors Induce Ceramide Accumulation and Sensitize H3K27 Mutant Diffuse Midline Glioma to Irradiation

El Malki, Khalifa; Charlotte Wehling, Pia; Alt, Francesca; Sandhoff, Roger; Zahnreich, Sebastian; Ustjanzew, Arsenij; Wilzius, Carolin; A. Brockmann, Marc; Wingerter, Arthur; Russo, Alexandra; Beck, Olaf; Sommer, Clemens; Ottenhausen, Malte; Frauenknecht, Katrin; Paret, Claudia; Faber, Jörg

doi:10.3390/ijms24129905

Public

Glucosylceramide Synthase Inhibitors Induce Ceramide Accumulation and Sensitize H3K27 Mutant Diffuse Midline Glioma to Irradiation

Published in International Journal of Molecular Sciences • Jun 8, 2023

Authors:

Khalifa El Malki

Pia Charlotte Wehling

Francesca Alt

Abstract

H3K27M mutant (mut) diffuse midline glioma (DMG) is a lethal cancer with no effective cure. The glycosphingolipids (GSL) metabolism is altered in these tumors and could be exploited to develop new therapies. We tested the effect of the glucosylceramide synthase inhibitors (GSI) miglustat and eliglus...

Subject

Sphingosine

Ceramide

Glioma

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