Osteoarthritic chondrocytes undergo a glycolysis-related metabolic switch upon exposure to IL-1b or TNF

Defois, A.; Bon, Nina; Charpentier, Alexandre; Georget, Mélina; Gaigeard, Nicolas; Blanchard, Frédéric; Hamel, Antoine; Waast, Denis; Armengaud, Jean; Renoult, Ophélie; Pecqueur, Claire; Maugars, Yves; Boutet, Marie‐Astrid; Guicheux, Jérôme; Vinatier, Claire

doi:10.1186/s12964-023-01150-z

Public

Osteoarthritic chondrocytes undergo a glycolysis-related metabolic switch upon exposure to IL-1b or TNF

Published in Cell Communication and Signaling • Jun 14, 2023

Authors:

A. Defois

Nina Bon

Alexandre Charpentier

Abstract

BACKGROUND: Osteoarthritis is an age-related disease that currently faces a lack of symptomatic treatment. Inflammation, which is mainly sustained by pro-inflammatory cytokines such as IL-1b, TNF, and IL-6, plays an important role in osteoarthritis progression. In this context, pro-inflammatory cyto...

Subject

Osteoarthritis

Inflammation

Proinflammatory cytokine

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