Monocytic MDSCs exhibit superior immune suppression via adenosine and depletion of adenosine improves efficacy of immunotherapy

Sadi Sarkar, Omar; Donninger, Howard; Al Rayyan, Numan; C. Chew, Lewis; F. Stamp, Bryce; Zhang, Xiang; G. Whitt, Aaron; Li, Chi; Barousse Hall, Melissa; A. Mitchell, Robert; Zippelius, Alfred; W. Eaton, John; Chesney, Jason; Yaddanapudi, Kavitha

doi:10.1126/sciadv.adg3736

Public

Monocytic MDSCs exhibit superior immune suppression via adenosine and depletion of adenosine improves efficacy of immunotherapy

Published in Science Advances • Jun 30, 2023

Authors:

Omar Sadi Sarkar

Howard Donninger

Numan Al Rayyan

Abstract

Immune checkpoint inhibitor (ICI) therapy is effective against many cancers for a subset of patients; a large percentage of patients remain unresponsive to this therapy. One contributing factor to ICI resistance is accumulation of monocytic myeloid-derived suppressor cells (M-MDSCs), a subset of inn...

Subject

Adenosine

Cancer research

Immune system

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