Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury

Yuan, Feifei; Peng, Wei; Yang, Yuying; Xu, Jiaqi; Liu, Yudong; Xie, Yong; Huang, Tingmo; Shi, Chaoran; Ding, Yinghe; Li, Chengjun; Qin, Tian; Xie, Shanshan; Zhu, Fengzhang; Lü, Hongbin; Huang, Jianjun; Hu, Jianzhong

doi:10.1186/s12974-023-02833-7

Public

Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury

Published in Journal of Neuroinflammation • Jun 30, 2023

Authors:

Feifei Yuan

Wei Peng

Yuying Yang

Abstract

BACKGROUND: Macrophage in the spinal cord injury (SCI) area imparts a chronic pro-inflammation effect that challenges the recovery of SCI. Previously, endothelial progenitor cell-produced exosomes (EPC-EXOs) have been noticed to facilitate revascularization and inflammation control after SCI. Howeve...

Subject

Macrophage polarization

Inflammation

Progenitor cell

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