Adequate versus deep response to ursodeoxycholic acid in primary biliary cholangitis: To what extent and under what conditions is normal alkaline phosphatase level associated with complication-free survival gain?

Corpechot, Christophe; Lemoinne, Sara; Soret, Pierre‐Antoine; E. Hansen, Bettina; M. Hirschfield, Gideon; Gulamhusein, Aliya; J. Montaño‐Loza, Aldo; Lytvyak, Ellina; Parés, Albert; Olivas, Ignasi; E. Eaton, John; T. Osman, Karim; Schramm, Christoph; Sebode, Marcial; W. Lohse, Ansgar; Ν. Dalekos, George; Gatselis, Nikolaos; Nevens, Frederik; Cazzagon, Nora; Zago, Alessandra; Paolo Russo, Francesco; Floreani, Annarosa; Abbas, Nadir; Trivedi, Palak; Thorburn, Douglas; Saffioti, Francesca; Barkai, László; Roccarina, Davide; Calvaruso, Vincenza; Fichera, A.; Delamarre, Adèle; Sobenko, Natalia; Villamil, Alejandra; Medina‐Morales, Esli; Bonder, Alan; Patwardhan, Vilas; Rigamonti, Cristina; Carbone, Marco; Invernizzi, Pietro; Cristoferi, Laura; van der Meer, Adriaan; de Veer, Rozanne; Zigmond, Ehud; Yehezkel, Eyal; E. Kremer, Andreas; Deibel, Ansgar; Bruns, Tony; Große, Karsten; Wetten, Aaron; Dyson, Jessica; Jones, David; Dumortier, Jérôme; Pageaux, Georges‐Philippe; de Lédinghen, Victor; Chazouillères, Olivier; Carrat, Fabrice; Global & ERN Rare-Liver PBC Study Groups, the

doi:10.1097/hep.0000000000000529

Public

Adequate versus deep response to ursodeoxycholic acid in primary biliary cholangitis: To what extent and under what conditions is normal alkaline phosphatase level associated with complication-free survival gain?

Published in Hepatology • Jul 3, 2023

Authors:

Christophe Corpechot

Sara Lemoinne

Pierre‐Antoine Soret

Abstract

BACKGROUND AND AIMS: Normal alkaline phosphatase (ALP) levels in ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC) are associated with better long-term outcome. However, second-line therapies are currently recommended only when ALP levels remain above 1.5 times the ...

Subject

Ursodeoxycholic acid

Medicine

Gastroenterology

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