Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis

Inamo, Jun; Keegan, Joshua; Griffith, Alec; Ghosh, Tusharkanti; Horisberger, Alice; Howard, Kaitlyn; Pulford, John; Murzin, Ekaterina; L. Hancock, Brandon; Helena Jonsson, A.; Seifert, Jennifer; L. Feser, Marie; M. Norris, Jill; Cao, Ye; Apruzzese, William; Louis Bridges, S.; P. Bykerk, Vivian; M. Goodman, Susan; T. Donlin, Laura; S. Firestein, Gary; Perlman, Harris; M. Bathon, Joan; B. Hughes, Laura; Tabechian, Darren; Filer, Andrew; Pitzalis, Costantino; H. Anolik, Jennifer; W. Moreland, Larry; M. Guthridge, Joel; A. James, Judith; B. Brenner, Michael; Raychaudhuri, Soumya; A. Sparks, Jeffrey; Accelerating Medicines Partnership RA/SLE Network, The; Michael Holers, V.; D. Deane, Kevin; A. Lederer, James; A. Rao, Deepak; Zhang, Fan

doi:10.1101/2023.07.03.547507

Public

Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis

Published in bioRxiv (Cold Spring Harbor Laboratory) • Jul 4, 2023

Authors:

Jun Inamo

Joshua Keegan

Alec Griffith

Abstract

Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease with currently no universally highly effective prevention strategies. Identifying pathogenic immune phenotypes in ‘At-Risk’ populations prior to clinical disease onset is crucial to establishing effective prevention strategies. Here...

Subject

Immunophenotyping

Rheumatoid arthritis

Medicine

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