α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure

Zhang, Naijin; Zhang, Ying; Xu, Jiaqi; Wang, Pengbo; Wu, Boquan; Lu, Saien; Lu, Xinxin; You, Shilong; Huang, Xinyue; Li, Mohan; Zou, Yuanming; Liu, Mengke; Zhao, Yuanhui; Sun, Guozhe; Wang, Wenbin; Geng, Danxi; Liu, Jingwei; Cao, Liu; Sun, Yingxian

doi:10.1038/s41422-023-00844-w

Public

α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure

Published in Cell Research • Jul 13, 2023

Authors:

Naijin Zhang

Ying Zhang

Jiaqi Xu

Abstract

The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac structure and contraction. However, the mechanism regulating this interaction in normal and failing hearts remains unknown. Lactate is a crucial energy substrate of the heart. Here, we identify that α-MHC unde...

Subject

Biology

Myosin

Function (biology)

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