Donanemab in Early Symptomatic Alzheimer Disease

R. Sims, John; A. Zimmer, Jennifer; D. Evans, Cynthia; Lu, Ming; Ardayfio, Paul; Sparks, JonDavid; M. Wessels, Alette; Shcherbinin, Sergey; Wang, Hong; Serap Monkul Nery, Emel; C. Collins, Emily; Solomon, Paul; Salloway, Stephen; G. Apostolova, Liana; Hansson, Oskar; Ritchie, Craig; A. Brooks, Dawn; Mintun, Mark; M. Skovronsky, Daniel; 2 Investigators, TRAILBLAZER-ALZ; Abreu, Rafael; Agarwal, Pinky; Aggarwal, Puja; Agronin, Marc; Allen, Alison; Altamirano, Dario; Alva, Gustavo; Andersen, James; Anderson, Allan; Anderson, Donald; Arnold, Jennifer; Asada, Takashi; Aso, Yasuhiro; Atit, Vikram; Ayala, Ricardo; Badruddoja, Michael; Badzio-jagiello, Hanna; Bajacek, Michal; Barton, David; Bear, David; Benjamin, Sabrina; Bergeron, Richard; Bhatia, Perminder; Black, Sandra; Block, Allan; Bolouri, Mohammad; Bond, Wendy; Bouthillier, Jean; Brangman, Sharon; Brew, Bruce; Brisbin, Sarah; Brisken, Toby; Brodtmann, Amy; Brody, Mark; Brosch, Jared; Brown, Celia; Brownstone, Paul; Bukowczan, Sylwia; Burns, Jeffrey; Cabrera, Alicia; Capote, Horace; Carrasco, Angel; Cevallos Yepez, Jose; Chavez, Eric; Chertkow, Howard; Chyrchel-paszkiewicz, Urszula; Ciabarra, Anthony; Clemmons, Edward; Cohen, Daniel; Cohen, Robert; Cohen, Ian; Concha, Mauricio; Costell, Brian; Crimmins, Denis; Cruz-pagan, Yvette; Cueli, Adolfo; Cupelo, Robert; Czarnecki, Maciej; Darby, David; Dautzenberg, P.l.j.; De Deyn, Peter; De La Gandara, Jose; Deck, Kenneth; Dibenedetto, David; Dibuono, Mark; Dinnerstein, Eric; Dirican, Ahmet; Dixit, Shanker; Dobryniewski, Jacek; Drake, Ryan; Drysdale, Peter; Duara, Ranjan; Duffy, John; Ellenbogen, Aaron; Faradji, Victor; Feinberg, Marc; Feldman, Robert; Fishman, Simon; Flitman, Stephen; Forchetti, Concetta; Fraga, Ivonne; Frank, Andrew; Frishberg, Benjamin; Fujigasaki, Hiroto; Fukase, Hiroyuki; Fumero, Ileana; Furihata, Kenichi; Galloway, Christopher; Gandhi, Rekha; George, Kristi; Germain, Marcel; Gitelman, Darren; Goetsch, Nicholas; Goldfarb, Danielle; Goldstein, Mark; Goldstick, Lawrence; Gonzalez Rojas, Yaneicy; Goodman, Ira; Greeley, David; Griffin, Carl; Grigsby, Eric; Grosz, Daniel; Hafner, Karl; Hart, David; Henein, Sam; Herskowitz, Brad; Higashi, Shinji; Higashi, Yasuto; Ho, Gilbert; Hodgson, Jonathan; Hohenberg, Mark; Hollenbeck, Larry; Holub, Richard; Hori, Tomokatsu; Hort, Jakub; Ilkowski, Jan; Jennifer Ingram, K.; Isaac, Mitchell; Ishikawa, Mitsunori; Janu, Lubos; Johnston, Mark; Julio, William; Justiz, William; Kaga, Tomotsugu; Kakigi, Tatsuya; Kalafer, Marvin; Kamijo, Mikiko; Kaplan, Jeffrey; Karathanos, Michael; Katayama, Sadao; Kaul, Siddharth; Keegan, Andrew; Kerwin, Diana; Khan, Uzma; Khan, Arifulla; Kimura, Noriyuki; Kirk, Gregory; Klodowska, Gabriela; Kowa, Hisatomo; Kutz, Christen; Kwentus, Joseph; Lai, Rosalyn; Lall, Ayesha; Lawrence, Mary; Lee, Elly; Leon, Ramon; Linker, Gary; Lisewski, Pawel; Liss, Jonathan; Liu, Collins; Losk, Scott; Lukaszyk, Ewelina; Lynch, Jennifer; Macfarlane, Stephen; Macsweeney, Josephine; Mannering, Nicholas; Markovic, Oto; Marks, Donald; Masdeu, Joseph; Matsui, Yutaka; Matsuishi, Kunitaka; Mcallister, Peter; Mcconnehey, Brock; Mcelveen, Alvin; Mcgill, Lora; Mecca, Adam; Mega, Michael; Mensah, Jason; Mickielewicz, Anatol; Minaeian, Artin; Mocherla, Bharat; Murphy, Cynthia; Murphy, Paul; Nagashima, Hirotaka; Nair, Anil; Nair, Malini; Nardandrea, John; Nash, Marshall; Nasreddine, Ziad; Nishida, Yoshihiko

doi:10.1001/jama.2023.13239

Public

Donanemab in Early Symptomatic Alzheimer Disease

Shared by NobleBlocks on Aug 8, 2023 • 12:00 AM UTC

Authors:

John R. Sims

Jennifer A. Zimmer

Cynthia D. Evans

Abstract

Importance There are limited efficacious treatments for Alzheimer disease. Objective To assess efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid plaque. Design, Setting, and Participants Multicenter (277 medical research centers/hospitals in 8 countries), randomiz...

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