Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions

Bernardi, Paolo; Gerle, Christoph; P. Halestrap, Andrew; A. Jonas, Elizabeth; Karch, Jason; Mnatsakanyan, Nelli; V. Pavlov, Evgeny; Sheu, Shey‐Shing; A. Soukas, Alexander

doi:10.1038/s41418-023-01187-0

Public

Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions

Published in Cell Death and Differentiation • Jul 17, 2023

Authors:

Paolo Bernardi

Christoph Gerle

Andrew P. Halestrap

Abstract

Abstract The mitochondrial permeability transition (mPT) describes a Ca 2+ -dependent and cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that allows diffusion of molecules up to 1.5 kDa in size. It is mediated by a non-selective channel, the mitochondrial perm...

Subject

Mitochondrial permeability transition pore

Permeability (electromagnetism)

Function (biology)

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